{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:55:05Z","timestamp":1790240105887,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,12]],"date-time":"2007-11-12T00:00:00Z","timestamp":1194825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the clinical utility of the first\u2010trimester biochemical markers of aneuploidy in their ability to predict subsequent delivery of a small\u2010for\u2010gestational age (SGA) infant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined singleton pregnancies with no chromosomal abnormality and with complete outcome data that had undergone screening for trisomy 21 by a combination of fetal nuchal translucency (NT) thickness and maternal serum free \u03b2\u2010human chorionic gonadotropin (\u03b2\u2010hCG) and pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) at 11 + 0 and 13 + 6 weeks' gestation. The biochemical markers were converted to multiples of the expected normal median (MoM) for a pregnancy of the same gestation. The association between free \u03b2\u2010hCG and PAPP\u2010A and the incidence of SGA were assessed by comparing the relative incidence at MoM cut\u2010offs and birth\u2010weight centile cut\u2010offs. At various marker levels the likelihood ratios (LR) for SGA were also calculated after excluding other adverse pregnancy complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 46 262 pregnancies resulting in live births with birth weight at or above the 10<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile, and 3539 below the 10<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile for gestation (SGA). There was a significant inverse association between the risk for SGA and maternal serum PAPP\u2010A MoM but not free \u03b2\u2010hCG MoM. At the 5<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile of the normal outcome group for PAPP\u2010A (0.415 MoM) the odds ratios for SGA below the 10<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup>, 5<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> and 3<jats:sup><jats:italic>rd<\/jats:italic><\/jats:sup> centiles of normal were 2.70, 3.21 and 3.66 and the respective detection rates for SGA were 12.0%, 14.0% and 16.0%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low levels of maternal serum PAPP\u2010A are associated, in the absence of an abnormal karyotype, with an increased risk for subsequent delivery of an SGA infant. Copyright \u00a9 2007 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.5165","type":"journal-article","created":{"date-parts":[[2007,11,12]],"date-time":"2007-11-12T13:49:15Z","timestamp":1194875355000},"page":"15-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["First\u2010trimester biochemical markers of aneuploidy and the prediction of small\u2010for\u2010gestational age fetuses"],"prefix":"10.1002","volume":"31","author":[{"given":"K.","family":"Spencer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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