{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:58:20Z","timestamp":1783133900823,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T00:00:00Z","timestamp":1200268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the association between the intrapulmonary circulation and the degree of lung growth in fetuses with congenital diaphragmatic hernia (CDH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010six fetuses with isolated left CDH at 22\u201329 weeks of gestation were studied. Four groups were defined according to lung\u2010to\u2010head ratio (LHR), expressed as the ratio of observed to expected LHR for gestational age (O\/E LHR). Pulsatility index (PI), peak systolic velocity (PSV), peak early\u2010diastolic reversed flow (PEDRF), end\u2010diastolic velocity (EDV), acceleration time (AT), time averaged velocity (TAV) and the ratio AT to ejection time (AT\/ET) were measured in all fetuses in the proximal arterial branch of both lungs. For analysis, Doppler values were converted to <jats:italic>Z<\/jats:italic>\u2010scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was possible to record all Doppler parameters from the contralateral lung of all CDH fetuses, and from the ipsilateral lung in 28 (77.7%). PEDRF significantly increased in relation to the decrease in O\/E LHR in both lungs (contralateral: <jats:italic>r<\/jats:italic> = \u2212 0.65, <jats:italic>P<\/jats:italic> = 0.01; ipsilateral: <jats:italic>r<\/jats:italic> = \u2212 0.43, <jats:italic>P<\/jats:italic> = 0.02). PI increased significantly with the reduction in O\/E LHR but only on the side contralateral to the hernia (<jats:italic>r<\/jats:italic> = \u2212 0.55, <jats:italic>P<\/jats:italic> = 0.02). In the ipsilateral pulmonary artery, PI values showed a significant overall increase but no differences were observed among the O\/E LHR groups. PSV, EDV and TAV were reduced in both lungs with respect to normal values, but no association was found with the O\/E LHR. No changes in AT or AT\/ET were observed in either lung.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PEDRF is quick and easy to calculate, and showed the strongest and most consistent correlation with O\/E LHR. The association between PEDRF and LHR might be an additional parameter that could help to establish prognosis in fetuses with CDH. Copyright \u00a9 2008 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.5201","type":"journal-article","created":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T15:19:04Z","timestamp":1200323944000},"page":"164-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Association between intrapulmonary arterial Doppler parameters and degree of lung growth as measured by lung\u2010to\u2010head ratio in fetuses with congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"31","author":[{"given":"O.","family":"Moreno\u2010Alvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hernandez\u2010Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Oros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Deprest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gratacos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.532"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(89)80713-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510290064038"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/prrv.2000.0070"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00228.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2688"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.4052"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/prrv.2000.0069"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.250"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.69"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70229-2"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90338-3"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(01)00368-2"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199706000-00016"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00134.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11010030.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.122413"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00327-3"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.57.6.811"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2735"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00100.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1711"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.5201","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.5201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T07:43:11Z","timestamp":1696750991000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.5201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1002\/uog.5201"],"URL":"https:\/\/doi.org\/10.1002\/uog.5201","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"2007-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}