{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:08:25Z","timestamp":1791594505013,"version":"4.3.4"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T00:00:00Z","timestamp":1198195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2008,1]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To describe the clinical history and ultrasound findings in women with ovarian Sertoli cell, Sertoli\u2013Leydig cell and Leydig cell tumors.<\/jats:p><\/jats:sec>Methods<\/jats:title>Women with a histological diagnosis of Sertoli cell tumor, Sertoli\u2013Leydig cell tumor or Leydig cell tumor who had undergone preoperative ultrasound examination were identified from the databases of each of three participating ultrasound centers. The tumors were characterized on the basis of ultrasound images, ultrasound reports and research protocols (when applicable) using the terms and definitions published by the International Ovarian Tumor Analysis (IOTA) group. In addition, all images were reviewed and described using pattern recognition.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 22 patients identified, 15 had Sertoli\u2013Leydig cell tumors, two had Sertoli cell tumors and five had Leydig cell tumors. Four patients were postmenopausal, one 48\u2010year\u2010old woman had undergone hysterectomy, 16 were of fertile age and one was a 4\u2010year\u2010old girl. Most patients (82%, 18\/22) had endocrine symptoms, the most common being bleeding disturbance (64%, 14\/22) and hirsutism (32%, 7\/22). Twenty\u2010two (96%) of 23 tumors (one woman had bilateral tumors) contained a solid component; 16 (70%) were purely solid. Pattern recognition showed that the Leydig cell tumors were small solid tumors (four of five had a largest diameter of 1\u20133 cm) and the two Sertoli cell tumors were somewhat larger solid tumors (4 cm and 7 cm); the Sertoli\u2013Leydig cell tumors were either small (3\u20134 cm) or medium\u2010sized (6\u20137 cm) solid tumors, or multilocular solid tumors of any size (3\u201318 cm) with purely solid areas mixed with areas of innumerable closely packed small cyst locules.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>On the basis of endocrine symptoms, the woman's age and ultrasound findings, it should be possible to suggest a correct preoperative diagnosis of Sertoli cell, Sertoli\u2013Leydig cell or Leydig cell tumors in many cases. Copyright \u00a9 2007 ISUOG. Published by John Wiley & Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.5227","type":"journal-article","created":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T12:16:44Z","timestamp":1198239404000},"page":"85-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli\u2013Leydig cell tumors and Leydig cell tumors"],"prefix":"10.1002","volume":"31","author":[{"given":"V. N.","family":"Demidov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lipatenkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Vikhareva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Van Holsbeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Timmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Valentin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3889-6_19"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00287.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.14050338.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10040282.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00123.x"}],"container-title":["Ultrasound in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.5227","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.5227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T03:42:46Z","timestamp":1697168566000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.5227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,21]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1002\/uog.5227"],"URL":"https:\/\/doi.org\/10.1002\/uog.5227","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,21]]},"assertion":[{"value":"2007-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}