{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T20:02:17Z","timestamp":1782590537450,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T00:00:00Z","timestamp":1198195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of plasma volume expansion (PVE) and nitric oxide (NO) donors, in addition to antihypertensive therapy for gestational hypertensive pregnancies complicated by intrauterine growth restriction (IUGR) with absent end\u2010diastolic flow (AEDF) in the umbilical artery (UA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a case\u2013control study into which 32 gestational hypertensive pregnancies with IUGR and AEDF were enrolled. Sixteen of these were treated with antihypertensive drugs, NO donors and PVE (Group A), and 16, matched for maternal age, gestational age and fetal conditions, were treated with antihypertensive drugs only (Group B). All patients underwent fetal and uteroplacental assessment and maternal echocardiography to evaluate total vascular resistance (TVR) and cardiac output before and 5\u201314 days after initiation of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 5\u201314 days of treatment, the maternal TVR in Group A fell from 2170 \u00b1 248 to 1377 \u00b1 110 <jats:italic>dynes<\/jats:italic>\u00b7s\u00b7cm<jats:sup>\u22125<\/jats:sup> (<jats:italic>P<\/jats:italic> &lt; 0.01), and that in Group B fell from 2090 \u00b1 260 to 1824 \u00b1 126 dynes\u00b7s\u00b7cm<jats:sup>\u22125<\/jats:sup> (<jats:italic>P<\/jats:italic> &lt; 0.01), with the reduction being greater in Group A than in Group B (<jats:italic>P<\/jats:italic> &lt; 0.01). There was a significant increase in cardiac output in Group A after 5\u201314 days of treatment vs. baseline (6.19 \u00b1 0.77 vs. 4.32 \u00b1 0.66, <jats:italic>P<\/jats:italic> &lt; 0.001), and, after treatment, cardiac output was significantly greater in Group A than it was in Group B (6.19 \u00b1 0.77 vs. 4.70 \u00b1 0.44, <jats:italic>P<\/jats:italic> &lt; 0.001). Reappearance of end\u2010diastolic flow in the UA occurred in 14\/16 patients in Group A but in no patients in Group B (87.5% vs. 0%, <jats:italic>P<\/jats:italic> &lt; 0.05). The interval between detection of UA\u2010AEDF and delivery was 28 \u00b1 16 days in Group A and 11 \u00b1 6 days in Group B (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Administration of NO donors and PVE in gestational hypertensive pregnancies affected by IUGR and UA\u2010AEDF appears to improve both maternal and fetal hemodynamics, inducing prolongation of gestation. Copyright \u00a9 2007 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.5234","type":"journal-article","created":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T13:16:35Z","timestamp":1198242995000},"page":"55-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Maternal and fetal hemodynamic effects induced by nitric oxide donors and plasma volume expansion in pregnancies with gestational hypertension complicated by intrauterine growth restriction with absent end\u2010diastolic flow in the umbilical artery"],"prefix":"10.1002","volume":"31","author":[{"given":"H.","family":"Valensise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Vasapollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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