{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:56:52Z","timestamp":1790434612028,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T00:00:00Z","timestamp":1206662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe our experience in cases with sonographic signs of fetal infection and with maternal serological \u2018immunity\u2019 to cytomegalovirus (CMV) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a bicenter study of six pregnant women referred for evaluation of suspected fetal infection. All cases had confirmed maternal serology for past exposure to CMV but no evidence of recent secondary CMV infection. All underwent sonographic evaluation as well as complete investigation for CMV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the women was 29 (range, 23\u201335) years and the mean gestational age at diagnosis was 23.5 weeks (range, 20\u201331) weeks. Sonographic findings included microcephaly, ventriculomegaly, periventricular calcifications and cystic lesions, echogenic bowel, hydrops and hepatosplenomegaly. Amniocentesis was performed in all cases for fetal karyotyping and viral assessment, and all were found by polymerase chain reaction to be positive for CMV infection. Four pregnancies were terminated following the parents' request. One pregnancy continued until intrauterine fetal death occurred 2 weeks after diagnosis. Postmortem was denied in all cases but one. One infant was delivered with evidence of severe cerebral palsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the presence of sonographic findings suggestive of fetal CMV infection, prompt investigation of amniotic fluid should follow even if maternal serology does not support recent maternal seroconversion. Copyright \u00a9 2008 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.5255","type":"journal-article","created":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T19:57:50Z","timestamp":1206734270000},"page":"417-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Secondary cytomegalovirus infection can cause severe fetal sequelae despite maternal preconceptional immunity"],"prefix":"10.1002","volume":"31","author":[{"given":"Y.","family":"Zalel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Gilboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Berkenshtat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Yoeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Auslander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Achiron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s00431-002-1115-5","article-title":"Congenital cytomegalovirus infection after recurrent infection: case reports and review of the literature","volume":"162","author":"Gaytant MA","year":"2003","journal-title":"Eur J Pediatr"},{"key":"e_1_2_5_3_2","first-page":"394","article-title":"Cytomegalovirus infection in pregnancy","volume":"17","author":"Raynor BD","year":"1993","journal-title":"Semin Perinatol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70401-5"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.8.1008"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2005.02.002"},{"key":"e_1_2_5_7_2","first-page":"694","article-title":"Early recurrent CMV infection with severe outcome to the fetus","volume":"7","author":"Benshushan A","year":"1998","journal-title":"Acta Obstet Gynecol Scand"},{"key":"e_1_2_5_8_2","first-page":"431","article-title":"Congenital CMV\u2014infection and hearing loss","volume":"54","author":"Lagasse N","year":"2000","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199203053261003"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00705.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.1.55"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.5.1227"},{"key":"e_1_2_5_13_2","first-page":"565","article-title":"The effects of cytomegalovirus infection during pregnancy on the developing human fetus","volume":"141","author":"Ornoy A","year":"2002","journal-title":"Harefuah"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105033441804"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1514"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.5255","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.5255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T01:50:18Z","timestamp":1697507418000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.5255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,28]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1002\/uog.5255"],"URL":"https:\/\/doi.org\/10.1002\/uog.5255","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,28]]},"assertion":[{"value":"2007-09-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}