{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T11:55:37Z","timestamp":1775390137932,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T00:00:00Z","timestamp":1215648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Umbilical venous blood flow could be considered a direct and physiological measurement of vascular placental function, representing the quantity of oxygen and nutrients reaching the fetus. The advent of high\u2010technology ultrasound and pulsed Doppler has overcome some of the limitations of early studies. Indeed, Doppler measurement of umbilical venous blood flow has been found to be accurate when compared with several gold standards for in\u2010vivo flow calculation. Nevertheless, small errors in volume flow components, the vessel area and the mean velocity, result in large errors in the calculation of volume flow. Therefore, technique standardization is of paramount importance. Validation studies in animal models have demonstrated accurate venous blood flow measurements by estimating the vessel's cross\u2010sectional area from perpendicular views of longitudinal sections of free\u2010floating portions of the cord. On the other hand, estimation of the mean velocity from the maximum velocity, rather than using the intensity\u2010weighted mean velocity, is less software\u2010dependent and more clearly defined, yielding estimates with more predictable and systematic errors. By adhering to <jats:italic>stringent<\/jats:italic> methodological recommendations, umbilical venous blood flow calculation has moderate to good intra\u2010 and interobserver reproducibility. Having been found to be accurate and reproducible, further studies are required to establish the clinical value of umbilical vein flow measurement. Copyright \u00a9 2008 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/uog.5306","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T09:26:34Z","timestamp":1215681994000},"page":"587-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Umbilical venous blood flow measurement: accuracy and reproducibility"],"prefix":"10.1002","volume":"32","author":[{"given":"F.","family":"Figueras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Hern\u00e1ndez\u2010Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Gratac\u00f3s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,10]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(84)90169-8"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1984.tb05891.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1986.tb07930.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb01398.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1994.04010049.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70098-0"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117356"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.5.1731"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09551.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90495-6"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197109000-00003"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0141-5425(82)90023-1"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30339"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(79)90014-0"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0306-3356(21)00590-2","article-title":"Fetal and utero\u2010placental blood flow","volume":"10","author":"Griffin D","year":"1983","journal-title":"Clin Obstet Gynaecol"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000242512"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365518709168907"},{"key":"e_1_2_5_19_2","first-page":"895","article-title":"Fetal blood flow in pregnancies complicated by intrauterine growth retardation","volume":"69","author":"Laurin J","year":"1987","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_20_2","first-page":"622","article-title":"Doppler evaluation of umbilical venous and arterial blood flow in the second and third trimesters of normal pregnancy","volume":"70","author":"Gerson AG","year":"1987","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70528-9"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00208.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.3.H1256"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00832.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1091"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199010000-00016"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.14040250.x"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70456-4"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00671.x"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2729"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13010052.x"},{"key":"e_1_2_5_32_2","first-page":"32","volume-title":"Doppler in Cardiology Physical Principles and Clinical Applications","author":"Hatle L","year":"1982"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1109\/10.284960"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.235035080"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(89)90095-1"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(95)00032-M"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(01)00357-X"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70504-7"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.938"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3847"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1243\/0954411991535004"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(90)90097-V"},{"key":"e_1_2_5_43_2","first-page":"559","article-title":"Limitations of coefficient of variation as index of measurement reliability","volume":"9","author":"Allison DB","year":"1993","journal-title":"Nutrition"},{"key":"e_1_2_5_44_2","volume-title":"Statistical Methods for Rates and Proportions","author":"Fleiss J","year":"1981"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00638.x"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15208.x"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.5306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.5306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T08:12:39Z","timestamp":1696752759000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.5306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,10]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1002\/uog.5306"],"URL":"https:\/\/doi.org\/10.1002\/uog.5306","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,10]]},"assertion":[{"value":"2007-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}