{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:57:37Z","timestamp":1778641057671,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,7,29]],"date-time":"2008-07-29T00:00:00Z","timestamp":1217289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The utility of a virtual reality system was examined in the visualization of three\u2010dimensional (3D) ultrasound images of fetal ambiguous genitalia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 2005, fetal ambiguous genitalia were diagnosed in four patients referred to our department for prenatal ultrasound assessment. The patients were examined by two\u2010dimensional (2D) and 3D ultrasound and, subsequently, the volumes obtained on 3D ultrasound were visualized in the BARCO I\u2010Space virtual reality system. This system projects stereoscopic images on three walls and the floor of a small \u2018room\u2019, allowing several viewers to see a 3D \u2018hologram\u2019 of the data being visualized. The results of 2D and 3D ultrasound examination and the virtual reality images of the I\u2010Space were compared with diagnoses made postpartum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all cases, prenatal diagnosis was unclear based on 2D ultrasound alone. Surface rendering of 3D data provided an impression of ambiguity, but diagnosis based on these data proved incorrect at birth in three cases. Conclusions based on the evaluation of 3D volumes in virtual reality best fitted the postpartum diagnosis in all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that by evaluation of the genitals in the I\u2010Space, a better impression of genital ambiguity can be established. Binocular depth perception appeared particularly useful in distinguishing either a micropenis or enlarged clitoris from labia minora, since it helps in the estimation of size and position. Therefore, we see potential for the application of virtual reality not only for the evaluation of fetal ambiguous genitalia, but in all those cases where depth perception would improve the visualization of anatomical structures. Copyright \u00a9 2008 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.5343","type":"journal-article","created":{"date-parts":[[2008,7,29]],"date-time":"2008-07-29T09:29:13Z","timestamp":1217323753000},"page":"510-514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Using virtual reality for evaluation of fetal ambiguous genitalia"],"prefix":"10.1002","volume":"32","author":[{"given":"C. M.","family":"Verwoerd\u2010Dikkeboom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H. J.","family":"Koning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. A. L.","family":"Groenenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. J.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Brezinka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Van Der Spek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A. P.","family":"Steegers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/13479830"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00179.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","unstructured":"Cruz\u2010NeiraC SandinD DefantiT.Surround\u2010screen projection\u2010based virtual reality: the design and implementation of the CAVE(\u2122). InProceedings of the 20thAnnual Conference on Computer Graphics and Interactive Techniques. ACM Press: New York 1993;135\u2013142.","DOI":"10.1145\/166117.166134"},{"key":"e_1_2_5_5_2","first-page":"112","volume-title":"Simulation and Visualisation on the Grid","author":"Koning AHJ","year":"1999"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00664.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.945"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2635"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-3-37"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-5-8"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.5343","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.5343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T08:10:28Z","timestamp":1696752628000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.5343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,29]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1002\/uog.5343"],"URL":"https:\/\/doi.org\/10.1002\/uog.5343","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,29]]},"assertion":[{"value":"2007-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}