{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:26:13Z","timestamp":1772767573697,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T00:00:00Z","timestamp":1222214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether cervical length measured by transvaginal ultrasonography predicts spontaneous preterm birth at &lt; 35 weeks' gestation in women with a history of spontaneous preterm birth, stratified by spontaneous preterm birth history subtype (preterm premature rupture of membranes (PPROM) or preterm labor with intact membranes at onset of labor).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included women with a history of spontaneous preterm birth that were subsequently pregnant with singleton gestations, compared with a low\u2010risk control group. Transvaginal ultrasonographic cervical lengths were measured at 24 to 30 weeks of gestation. The primary outcome was spontaneous preterm birth at &lt; 35 weeks. Secondary outcomes included spontaneous preterm birth at &lt; 37 weeks and &lt; 34 weeks, low birth weight, Cesarean delivery and perinatal morbidity and mortality. Multiple logistic regression analysis was used to control for potential confounders and calculate odds ratios and 95% confidence intervals. Receiver\u2013operating characteristics (ROC) curves were used to determine the best cut\u2010off for transvaginal ultrasound cervical length in predicting spontaneous preterm birth at &lt; 35 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with a history of spontaneous preterm birth with intact membranes at onset of labor (<jats:italic>n<\/jats:italic> = 42) had a shorter cervical length (3.28 cm) than women with a history of spontaneous preterm birth with PPROM at onset of labor (n = 48, cervical length 3.77 cm; P = 0.019), and both subgroups had shorter cervical lengths than the low\u2010risk control group (<jats:italic>n<\/jats:italic> = 103, cervical length 4.30 cm; <jats:italic>P<\/jats:italic> &lt; 0.0001). Both subgroups were associated with spontaneous preterm birth at &lt; 35 weeks, &lt; 37 weeks, &lt; 34 weeks and birth weight &lt; 2500 g. ROC curves determined that the best cut\u2010off for cervical length to predict spontaneous preterm birth at &lt; 35 weeks was 3.0 cm. By multiple logistic regression analysis, the only independent predictors of spontaneous preterm birth at &lt; 35 weeks were cervical length &lt; 3.0 cm, a history of spontaneous preterm birth and antepartum bleeding in the current pregnancy. In women with a history of spontaneous preterm birth, a cervical length as measured by transvaginal ultrasonography of &lt; 3.0 cm had a sensitivity of 63.6%, specificity of 77.2%, positive predictive value of 28.0% and negative predictive value of 93.8%, for preterm birth at &lt; 35 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with a history of spontaneous preterm birth with preterm labor and intact membranes at the onset of labor have shorter cervices than women with a history of spontaneous preterm birth and PPROM at the onset of labor, and both groups have shorter cervices than a low\u2010risk control group. Both groups of women with a history of spontaneous preterm birth have an increased risk of recurrent spontaneous preterm birth at &lt; 35 weeks, and this is predicted by a transvaginal ultrasound cervical length of &lt; 3.0 cm. Copyright \u00a9 2008 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.6143","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T10:55:51Z","timestamp":1222253751000},"page":"640-645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Use of transvaginal ultrasonography to predict preterm birth in women with a history of preterm birth"],"prefix":"10.1002","volume":"32","author":[{"given":"J. M. 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