{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:32:53Z","timestamp":1769513573273,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T00:00:00Z","timestamp":1222214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To establish longitudinal reference ranges for the fetal celiac and splenic arteries flow velocity and pulsatility index (PI), and to determine their hemodynamic relationship to venous liver perfusion and distribution and to other essential arteries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective longitudinal study of 161 low\u2010risk pregnancies. Doppler recordings of the celiac and splenic arteries were made on three to five occasions at 3\u20135\u2010week intervals to establish reference ranges for blood velocity and PI measurements. Peak systolic velocity in the ductus venosus, a shunt between the umbilical and inferior caval veins, was used to represent the umbilicocaval (i.e. portocaval) pressure gradient, and the left portal vein blood velocity represented the umbilical distribution to the right liver lobe. The correlations between the celiac, splenic and hepatic arteries were determined, and their association with the middle cerebral and umbilical artery PIs (MCA\u2010PI and UA\u2010PI) was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Longitudinal reference ranges for the fetal celiac and splenic arteries were established based on 510 and 521 observations, respectively, during gestational weeks 21\u201339. Terms for calculating conditional reference ranges to be used for repeat observations are provided. Celiac and splenic artery PIs were low when portocaval pressure and umbilical supply to the right lobe were low (<jats:italic>P<\/jats:italic>&lt; 0.0001). Their peak systolic velocity and PI were correlated (<jats:italic>r<\/jats:italic>= 0.7 (95% CI, 0.6\u20130.8) and<jats:italic>r<\/jats:italic>= 0.5 (95% CI, 0.3\u20130.6), respectively), while the PI of the hepatic artery correlated weakly with those of the celiac and splenic arteries. They were positively associated with the MCA\u2010PI and UA\u2010PI (<jats:italic>P<\/jats:italic>&lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We provide longitudinal reference ranges for the fetal celiac and splenic arteries Doppler measurements and show that they are involved in maintaining portal liver perfusion independently from the hepatic artery. Copyright \u00a9 2008 ISUOG. 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