{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:21:46Z","timestamp":1788848506667,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,10,27]],"date-time":"2008-10-27T00:00:00Z","timestamp":1225065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study was conducted to assess the role of pelvic ultrasound variables in discriminating between normal girls and girls with different forms of sexual precocity, and to establish reliable cut\u2010off limits of pelvic ultrasound measurements for differentiating between these conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010eight girls with different forms of sexual precocity (23 with premature thelarche, 15 with premature pubarche and 50 with central precocious puberty) were enrolled. All diagnoses were based on clinical examination with confirmation using the gonadotropin\u2010releasing hormone\u2010stimulation test. Additionally, 81 prepubertal girls, aged 0\u201310 years, were included as a control group. For statistical analysis and to facilitate comparisons, the groups were subdivided by age intervals (0\u20136, &gt; 6\u20138 and &gt; 8\u201310 years). All subjects underwent pelvic ultrasound examination for the measurement of uterine length, uterine volume, ovarian volume and the anteroposterior diameter at the fundus divided by the anteroposterior diameter at the cervix (fundal\/cervical ratio, (F\/C)). Finally, the morphological appearance of the ovaries was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with central precocious puberty had significantly higher values for all the ultrasound variables (with the exception of uterine length in the 1\u20136\u2010year age group) in comparison to normal girls. Patients with premature thelarche and patients with premature pubarche showed similar pelvic ultrasound parameters to those of normal girls. Ovarian volume was the best parameter for identifying patients with central precocious puberty (a cut\u2010off of 3.04 cm<jats:sup>3<\/jats:sup> had a sensitivity of 100% and a specificity of 97.1% for age interval 0\u20136 years, a cut\u2010off of 3.35 cm<jats:sup>3<\/jats:sup> had a sensitivity of 100% and a specificity of 89.5% for age interval &gt; 6\u20138 years, and a cut\u2010off of 4.46 cm<jats:sup>3<\/jats:sup> had a sensitivity of 80.8% and a specificity of 88.5% for age interval &gt; 8\u201310 years). Uterine length was the best parameter for distinguishing between patients with central precocious puberty and patients with premature thelarche (a cut\u2010off of 3.185 cm had a sensitivity of 85.7% and a specificity of 91.7% for age interval 0\u20136 years, and a cut\u2010off of 3.83 cm had a sensitivity of 82.4% and a specificity of 90.9% for age interval &gt; 6\u20138 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ultrasound examination of the uterus and ovaries could serve as a complementary tool for the diagnosis of central precocious puberty and, consequently, for the early initiation of appropriate treatment. Copyright \u00a9 2008 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.6148","type":"journal-article","created":{"date-parts":[[2008,10,27]],"date-time":"2008-10-27T08:38:44Z","timestamp":1225096724000},"page":"819-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Evaluation of pelvic ultrasonography in the diagnosis and differentiation of various forms of sexual precocity in girls"],"prefix":"10.1002","volume":"32","author":[{"given":"M.","family":"Badouraki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Christoforidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Economou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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