{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:28:28Z","timestamp":1764131308593},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,11,14]],"date-time":"2008-11-14T00:00:00Z","timestamp":1226620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the hypothesis that, in diabetic pregnancies, left atrial shortening fraction (LASF) is decreased in fetuses with myocardial hypertrophy, compared to those without hypertrophy and to fetuses of non\u2010diabetic mothers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fetal echocardiography was performed in women with pre\u2010existing or gestational diabetes and in non\u2010diabetic controls between 25 weeks' gestation and term. LASF was calculated using the formula: (end\u2010systolic diameter\u2014end\u2010diastolic diameter)\/end\u2010systolic diameter, and data were compared between diabetic women with and without fetal myocardial hypertrophy and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population comprised 53 diabetic women and 45 controls. Out of the 53 fetuses of diabetic women, 14 had myocardial hypertrophy and 39 had normal septal thickness. Gestational age at the time of examination did not differ significantly between the control group and the two diabetic subgroups (<jats:italic>P<\/jats:italic> = 0.57). Fetuses with myocardial hypertrophy presented a mean ( \u00b1 SD) LASF of 0.32 \u00b1 0.11, those without myocardial hypertrophy 0.46 \u00b1 0.12, and those of normal mothers 0.53 \u00b1 0.09 (<jats:italic>P<\/jats:italic> &lt; 0.001). A significant inverse linear correlation was observed between LASF and septal thickness (<jats:italic>r<\/jats:italic> = \u2212 0.51, <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In diabetic pregnancies, LASF is lower in fetuses with myocardial hypertrophy than it is in those without hypertrophy and in fetuses of non\u2010diabetic women, suggesting that LASF could be a useful alternative parameter in the assessment of fetal diastolic function. Copyright \u00a9 2008 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.6154","type":"journal-article","created":{"date-parts":[[2008,11,14]],"date-time":"2008-11-14T14:58:14Z","timestamp":1226674694000},"page":"182-187","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Left atrial shortening fraction in fetuses with and without myocardial hypertrophy in diabetic pregnancies"],"prefix":"10.1002","volume":"33","author":[{"given":"P.","family":"Zielinsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Luchese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Manica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"A. 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