{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:40:01Z","timestamp":1792989601879,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T00:00:00Z","timestamp":1228953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess cardiac function by means of the modified myocardial performance index (Mod\u2010MPI) in fetuses of pre\u2010eclamptic mothers without intrauterine growth restriction and to compare this with values from normal controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted including a total of 72 fetuses at between 26 and 40 weeks' gestation. Forty fetuses of healthy mothers were assigned as the control group (Group I) while 15 fetuses of mildly pre\u2010eclamptic mothers constituted Group II and 17 fetuses of severely pre\u2010eclamptic mothers constituted Group III. Two\u2010dimensional gray\u2010scale and Doppler fetal echocardiography was used to exclude cardiac anomalies and calculate the Mod\u2010MPI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean \u00b1 SD Mod\u2010MPI values of Groups I, II and III were 0.43 \u00b1 0.045, 0.44 \u00b1 0.064 and 0.44 \u00b1 0.064, respectively (<jats:italic>P<\/jats:italic> = 0.680). The mean aortic peak systolic velocity (PSV), the mean mitral valve early ventricular filling (E\u2010wave) and active atrial filling (A\u2010wave) peak velocities were significantly lower in fetuses of severely pre\u2010eclamptic mothers than in fetuses of mildly pre\u2010eclamptic mothers and control fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The fetal global myocardial function assessed by Mod\u2010MPI does not seem to change in mild or severe pre\u2010eclampsia. The lower mitral E\u2010wave and A\u2010wave peak velocities and the lower aortic PSV seem to reflect the increased cardiac afterload against which the fetal heart has to work, rather than systolic or diastolic cardiac dysfunction, in the fetuses of severely pre\u2010eclamptic mothers. Copyright \u00a9 2008 ISUOG. 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