{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:36:27Z","timestamp":1769578587628,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T00:00:00Z","timestamp":1230508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine if fetal growth during the second trimester predicts poor pregnancy and neonatal outcome in patients with low first\u2010trimester serum pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) and a euploid fetus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified all patients with first\u2010trimester PAPP\u2010A &lt; 5<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile who had undergone first\u2010 and second\u2010trimester ultrasound examination. We excluded multiple pregnancies and those with aneuploidy or major anomalies identified before or after birth. We compared pregnancies with and without ultrasound markers for fetal growth restriction at 18\u201324 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 239 patients with low PAPP\u2010A, 25 (10.5%) of whom had evidence of fetal growth restriction at 18\u201324 weeks. These 25 cases had significantly higher rates of third\u2010trimester small\u2010for\u2010gestational age (SGA) fetus, gestational hypertension, preterm birth, indicated preterm birth, low birth weight and birth weight centiles, 1\u2010min Apgar score &lt; 7, neonatal intensive care unit admission and fetal or neonatal death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among patients with low first\u2010trimester PAPP\u2010A and a euploid fetus, fetal growth in the second trimester can predict poor obstetric and neonatal outcome. Copyright \u00a9 2008 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.6274","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T17:39:09Z","timestamp":1230745149000},"page":"34-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Second\u2010trimester fetal growth as a predictor of poor obstetric and neonatal outcome in patients with low first\u2010trimester serum pregnancy\u2010associated plasma protein\u2010A and a euploid fetus"],"prefix":"10.1002","volume":"33","author":[{"given":"N. S.","family":"Fox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Shalom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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