{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:22:41Z","timestamp":1791825761925,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T00:00:00Z","timestamp":1240272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the relationship of first\u2010trimester uterine artery Doppler indices with subsequent delivery of small\u2010for\u2010gestational age (SGA) neonates or intrauterine growth restriction (IUGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study in which uterine artery Doppler assessment was performed at 11\u201314 weeks in 3010 women with singleton pregnancies. Resistance indices (RI) and incidence of bilateral notching were compared between women with normal pregnancies (<jats:italic>n<\/jats:italic> = 2445) and those who delivered: SGA neonates (birth weight &lt; 10<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile) (<jats:italic>n<\/jats:italic> = 377); SGA neonates who had been affected by pre\u2010eclampsia (<jats:italic>n<\/jats:italic> = 27); IUGR neonates (birth weight &lt; 10<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile and abnormal Doppler indices) with delivery \u2265 37 weeks (<jats:italic>n<\/jats:italic> = 62); and IUGR neonates requiring preterm delivery (delivery &lt; 37 weeks) (<jats:italic>n<\/jats:italic> = 36).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The first\u2010trimester uterine artery mean RI and prevalence of bilateral notching were significantly higher in women destined to deliver SGA neonates than in women with normal pregnancies (median uterine artery RI, 0.74 vs. 0.70, <jats:italic>P<\/jats:italic> &lt; 0.001; prevalence of bilateral notches, 56% vs. 43%, <jats:italic>P<\/jats:italic> &lt; 0.001). The areas under the receiver\u2013operating characteristics curves for the prediction of SGA without pre\u2010eclampsia, IUGR, preterm IUGR and SGA with pre\u2010eclampsia were 0.602, 0.687, 0.776 and 0.708, respectively. There was a statistically significant inverse relationship between mean uterine artery RI and gestational age at delivery in the SGA pregnancies without pre\u2010eclampsia (<jats:italic>R<\/jats:italic> = \u2212 0.329, <jats:italic>P<\/jats:italic> = 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a significant relationship between first\u2010trimester uterine artery Doppler RI and the subsequent development of SGA. The sensitivity of first\u2010trimester uterine artery Doppler is greater for SGA with pre\u2010eclampsia than it is for IUGR alone. This could be because these two entities may have different underlying placental abnormalities that are detected variably on first\u2010trimester uterine artery Doppler evaluation. Copyright \u00a9 2009 ISUOG. 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