{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T22:26:25Z","timestamp":1775773585274,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T00:00:00Z","timestamp":1241654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine <jats:italic>reference ranges of fetal nasal bone length (NBL) in a Chinese population and to assess the value of NBL measurement in screening for chromosomal defects in the first trimester.<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective study the fetal profile was examined and the fetal NBL and crown\u2013rump length (CRL) were measured in Chinese women presenting with singleton pregnancies for first\u2010trimester screening for aneuploidy between January 2004 and June 2007. Screening was performed on the basis of nuchal translucency (NT) measurement and maternal serum free \u03b2\u2010human chorionic gonadotropin and pregnancy\u2010associated plasma protein\u2010A levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NBL was measured in 7543 fetuses, of which 7517 were euploid. The best fit equation for median NBL in euploid fetuses in relation to CRL was: NBL <jats:italic>(mm)<\/jats:italic> = 0.4593 + (0.0186 \u00d7 <jats:italic>CRL<\/jats:italic><jats:italic>(mm)<\/jats:italic>). The NBL for gestational age (GA, in days) was given by the equation <jats:italic>NBL<\/jats:italic><jats:italic>(mm)<\/jats:italic> = 0.2392 + (0.0027 \u00d7 <jats:italic>GA<\/jats:italic>). There was no correlation between <jats:italic>log<\/jats:italic><jats:sub>10<\/jats:sub>(NBL multiples of the median (MoM)) and <jats:italic>log<\/jats:italic><jats:sub>10<\/jats:sub>(NT MoM) in unaffected pregnancies (<jats:italic>r<\/jats:italic> = \u2212 0.009; <jats:italic>P<\/jats:italic> = 0.43). Only two of the 11 cases with trisomy 21 had an NBL outside the 5<jats:sup>th<\/jats:sup> or 95<jats:sup>th<\/jats:sup> centiles of the reference range for euploid fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reference ranges for NBL in a Chinese population suitable for screening for aneuploidy between 11 and 13 + 6 weeks' gestation have been derived. The NBL in Chinese fetuses is similar to that of other ethnic groups. However, unlike the determination of presence vs. absence of the nasal bone, NBL measurement is unlikely to further improve screening for aneuploidy. Copyright \u00a9 2009 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.6376","type":"journal-article","created":{"date-parts":[[2009,5,7]],"date-time":"2009-05-07T15:17:20Z","timestamp":1241709440000},"page":"33-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["First\u2010trimester fetal nasal bone length in an ethnic Chinese population"],"prefix":"10.1002","volume":"34","author":[{"given":"D. S.","family":"Sahota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Y.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. W.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. W.","family":"Law","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Y.","family":"Fung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. K.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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