{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:56:52Z","timestamp":1784404612243,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T00:00:00Z","timestamp":1252022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate cervical length and gestational age as predictors of intra\u2010amniotic inflammation in patients admitted because of preterm labor and intact membranes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010three pregnant women with preterm labor and intact membranes were included in our study. Cervical length was measured on admission by transvaginal sonography and transabdominal amniocentesis was performed within the first 48 h following admission. Positive amniotic fluid cultures defined intra\u2010amniotic infection. Levels of intra\u2010amniotic interleukin\u20106 (IL\u20106) were measured, and a receiver\u2013operating characteristics (ROC) curve was constructed to determine the best cut\u2010off point of IL\u20106 for predicting intra\u2010amniotic infection. This value was then used as a basis for determining a cut\u2010off of IL\u20106 for defining intra\u2010amniotic inflammation. Considering inflammatory status, perinatal outcomes were evaluated and compared. Logistic regression was used to investigate associations of different explanatory variables with inflammatory status. A non\u2010invasive approach for detection of intra\u2010amniotic inflammation in women admitted because of preterm labor with intact membranes was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intra\u2010amniotic infection and inflammation rates were 14% and 28%, respectively. ROC curve analysis showed that the best cut\u2010off value for IL\u20106 was 13.4 ng\/mL for predicting intra\u2010amniotic infection, which was comparable to the cut\u2010off of 11.3 ng\/mL reported previously by other authors (which we used to define inflammation). Regardless of the intra\u2010amniotic microbial status, perinatal outcomes in women who developed intra\u2010amniotic inflammation were worse than in those who did not. Cervical length &lt; 15 mm and gestational age at admission &lt; 28 weeks were independently associated with intra\u2010amniotic inflammation. A strategy considering these two non\u2010invasive parameters (either women admitted &lt; 28 weeks or women admitted between \u2265 28 and &lt; 32 weeks with a cervical length &lt; 15 mm) could detect 84.0% of women with intra\u2010amniotic inflammation with a positive predictive value of 48.8%, providing improved diagnostic indices compared to either variable considered alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cervical length and gestational age at admission can be used as a non\u2010invasive method to assess the risk of intra\u2010amniotic inflammation in preterm labor and intact membranes. Copyright \u00a9 2009 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.6437","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T08:34:37Z","timestamp":1252053277000},"page":"441-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Cervical length and gestational age at admission as predictors of intra\u2010amniotic inflammation in preterm labor with intact membranes"],"prefix":"10.1002","volume":"34","author":[{"given":"M.","family":"Palacio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Cobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Filella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Navarro\u2010Sastre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ribes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gratac\u00f3s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,9,4]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-956773"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117680"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/13506120500223241"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.11.047"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70269-8"},{"key":"e_1_2_5_7_2","first-page":"941","article-title":"The relationship of amniotic fluid cytokines and preterm delivery, amniotic fluid infection, histologic chorioamnionitis, and chorioamnion infection","volume":"81","author":"Hillier SL","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.10.624"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2006.002"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3837"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70057-5"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90009-8"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.118654"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/145.1.1"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80239-3"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90409-2"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(00)00064-4"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.01.017"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04234-3"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050600852668"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.6437","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.6437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T04:27:06Z","timestamp":1695961626000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.6437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1002\/uog.6437"],"URL":"https:\/\/doi.org\/10.1002\/uog.6437","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,4]]},"assertion":[{"value":"2009-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-09-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}