{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T05:16:45Z","timestamp":1774243005019,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The primary objective was to assess the accuracy of prenatal examination in detecting and characterizing perinatal solid tumors of the thoracoabdominopelvic region. Secondary objectives were to describe the epidemiology, clinical characteristics and outcome of these tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective multicenter study of all patients with a thoracic, abdominal or pelvic tumor diagnosed prenatally or within the first 3\u2009months after birth in the \u00cele\u2010de\u2010France area between January 2010 and May 2021. The gestational age at which a mass was detected on prenatal imaging, or the postnatal age at which the first tumor\u2010related sign or symptom was noted, in addition to the timing of postnatal diagnostic confirmation (clinicoradiological or pathological), were extracted from patient medical files.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 153 tumors were identified. An associated congenital malformation was identified in 14 (9%) infants and four (3%) had a known germline pathogenic variant. The main tumor locations were adrenal gland (43%), extra\u2010adrenal and extrarenal retroperitoneum (12%) and kidney (12%). The most common diagnoses were neuroblastoma (93\/153 (61%)) (including 65\u00a0adrenal, 20 extra\u2010adrenal retroperitoneal and eight thoracic\/mediastinal), hepatoblastoma (10\/153 (7%)), teratoma (10\/153 (7%)), nephroblastoma (8\/153 (5%)) and congenital mesoblastic nephroma (7\/153 (5%)). In 35% (53\/153) of cases, a mass was detected prenatally (mainly during the third trimester (62%)) and the diagnosis was confirmed at a median of 9 (interquartile range (IQR), 2\u201320) days after birth. Tumor detection was postnatal in 65% (100\/153) of cases, mainly on the basis of tumor mass syndrome (39%) or tumor palpation by parents or during a routine medical visit (36%), and occurred at a median of 73 (IQR, 39\u2013104) days after birth. Distant metastasis was noted in 4% (2\/53) of cases with a prenatal mass and in 36% (36\/100) of cases detected postnatally. Five medical terminations of pregnancy for a compressive tumor were reported, in addition to one\n                      <jats:italic>in\u2010utero<\/jats:italic>\n                      fetal demise. Five (3%) neonates required early supportive intensive care due to respiratory distress, arterial hypertension, intestinal perforation or intestinal obstruction. At a median follow\u2010up of 5 (range, 0\u201314) years, 136 (89%) patients remained alive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Only 35% of perinatal thoracic, abdominal and pelvic tumors were detected before birth. Although mainly malignant, their prognosis was largely favorable. Improving early detection may assist postnatal multidisciplinary management and parental guidance. \u00a9 2025 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70000","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T09:15:39Z","timestamp":1755940539000},"page":"499-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prenatal diagnosis and postnatal management of perinatal thoracoabdominopelvic tumors: multicenter experience"],"prefix":"10.1002","volume":"66","author":[{"given":"C.","family":"Khawand","sequence":"first","affiliation":[{"name":"Department of Obstetrics Fetal Medicine and Surgery, Necker\u2010Enfants Malades Hospital, AP\u2010HP, Paris\u2010Cit\u00e9 University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Orbach","sequence":"additional","affiliation":[{"name":"SIREDO Oncology Center (Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer), Institut Curie PSL University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Berrebi","sequence":"additional","affiliation":[{"name":"Department of Pathology Robert\u2010Debr\u00e9 and Necker\u2010Enfants Malades Hospital, AP\u2010HP, Paris\u2010Cit\u00e9 University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Branchereau","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Bic\u00eatre Hospital, AP\u2010HP, Paris\u2010Saclay University  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mussini","sequence":"additional","affiliation":[{"name":"Department of Pathology Bic\u00eatre Hospital, AP\u2010HP, Paris\u2010Saclay University  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Brisse","sequence":"additional","affiliation":[{"name":"Imaging Department, Institut Curie PSL University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gr\u00e9vent","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology Necker\u2010Enfants Malades Hospital, AP\u2010HP, Paris\u2010Cit\u00e9 University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7890-3790","authenticated-orcid":false,"given":"J.\u2010M.","family":"Jouannic","sequence":"additional","affiliation":[{"name":"Fetal Medicine Department, Armand\u2010Trousseau Hospital, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-0047","authenticated-orcid":false,"given":"A.","family":"Vivanti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Antoine\u2010B\u00e9cl\u00e8re Hospital, AP\u2010HP, Paris\u2010Saclay University  Clamart France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Minard\u2010Colin","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Oncology Gustave Roussy Cancer Campus, Paris\u2010Saclay University  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Ville","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Fetal Medicine and Surgery, Necker\u2010Enfants Malades Hospital, AP\u2010HP, Paris\u2010Cit\u00e9 University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sarnacki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Urology and Transplantation, Necker\u2010Enfants Malades Hospital, AP\u2010HP, Paris\u2010Cit\u00e9 University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Collaborators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2020.101697"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1122"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001692"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30623"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14164007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.11.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5260"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000305096"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10502"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31124"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1094"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2012.03.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20985"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24709"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-003-1048-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-013-3424-3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-1795"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24555"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2023.113451"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70236-5"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.662"},{"issue":"2","key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.oncohp.2013.10.008","article-title":"Tumeur et d\u00e9veloppement (TED)\u00a0: un enregistrement national des associations de cancers p\u00e9diatriques et de pathologies malformatives","volume":"2","author":"Bourdeaut F","year":"2014","journal-title":"Rev Oncol H\u00e9matol P\u00e9diatr"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970715)80:2<304::AID-CNCR19>3.0.CO;2-Y"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-015-3470-1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-011-0073-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4590"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02132"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-008-9001-8"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-020-04678-1"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30287"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.70000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:34:41Z","timestamp":1761237281000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.70000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,23]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/uog.70000"],"URL":"https:\/\/doi.org\/10.1002\/uog.70000","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,23]]},"assertion":[{"value":"2025-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}