{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:23:36Z","timestamp":1791915816147,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The corpus callosum (CC) is an interhemispheric structure that facilitates communication between the two cerebral hemispheres. Anomalies of the CC are frequent and associated with a wide spectrum of altered neurodevelopmental outcomes. However, variability in diagnostic criteria and the lack of standardized management strategies create challenges for clinicians and anxiety for expectant parents. This study aimed to establish an international consensus on the prenatal evaluation, diagnosis and management of fetal CC abnormalities using a structured Delphi methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A three\u2010round Delphi process was conducted among an international panel of fetal medicine experts, identified based on clinical expertise and publication history. Structured statements regarding CC evaluation, diagnosis and management were developed through expert input and a scoping literature review. The statements were iteratively refined and scored by the panel using a five\u2010point Likert scale in the first two rounds. During the final round, consensus was defined as &gt;\u200970% agreement among participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010five experts participated in the first round, with 43 (78.2%) experts completing the entire process. Key consensus findings included the incorporation of obtaining a sagittal view of the brain in routine ultrasound screening (72.4% agreement), without requiring measurement even when an anomaly is suspected (93.1% agreement), but instead with recommended referral to a specialist (100% agreement). For diagnostic ultrasound, three\u2010dimensional ultrasound imaging (72.4% agreement) and transvaginal ultrasound evaluation (82.8% agreement) were recommended, with targeted measurements of CC length in the case of a subjective impression of abnormal size (82.8% agreement). However, it was agreed that there is no consensus on the reference chart or cut\u2010off values to be used for defining abnormal CC length (86.2% and 89.3% agreement, respectively). In terms of management, it was agreed that both an invasive genetic workup and magnetic resonance imaging (MRI) should be offered in case of suspected dysgenesis of the CC (100% agreement). MRI should be performed if the CC appears to be too short (100% agreement), thin (100% agreement) or thick (92.0% agreement). In the case of an isolated CC with heterogeneous echogenicity, an infectious workup is recommended (86.2% agreement).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study provides a structured framework for the evaluation and management of fetal CC abnormalities. By standardizing approaches to imaging and management, the recommendations aim to improve diagnostic accuracy, optimize patient outcomes and reduce unnecessary interventions. Further prospective studies are needed to validate these recommendations and assess their impact on clinical care. \u00a9 2025 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70003","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T09:55:48Z","timestamp":1755942948000},"page":"582-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prenatal evaluation, diagnosis and management of fetal corpus callosal abnormalities: international\n                    <scp>Delphi<\/scp>\n                    consensus"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8583-2054","authenticated-orcid":false,"given":"R.","family":"Corroenne","sequence":"first","affiliation":[{"name":"LUMIERE Platform, Necker\u2010Enfants Malades Hospital University of Paris  Paris France"},{"name":"Department of Obstetrics &amp; Gynecology Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5102-6062","authenticated-orcid":false,"given":"D.","family":"Paladini","sequence":"additional","affiliation":[{"name":"Fetal Medicine &amp; Surgery Unit, Istituto G. Gaslini  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-1435","authenticated-orcid":false,"given":"I.","family":"Papastefanou","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health School of Life Course and Population Sciences, Faculty of Life Sciences &amp; Medicine, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9089-7119","authenticated-orcid":false,"given":"R.","family":"Chaoui","sequence":"additional","affiliation":[{"name":"Center for Prenatal Diagnosis and Human Genetics  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-8129","authenticated-orcid":false,"given":"L.","family":"Pomar","sequence":"additional","affiliation":[{"name":"Ultrasound and Fetal Medicine Unit, Department Woman\u2010Mother\u2010Child Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"},{"name":"School of Health Sciences (HESAV), HES\u2010SO University of Applied Sciences and Arts Western Switzerland  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-6654","authenticated-orcid":false,"given":"L.","family":"Guibaud","sequence":"additional","affiliation":[{"name":"Pediatric and Fetal Imaging, H\u00f4pital Femme M\u00e8re Enfant  Lyon\u2010Bron Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9868-3548","authenticated-orcid":false,"given":"K.","family":"Krajden Haratz","sequence":"additional","affiliation":[{"name":"Division of Ultrasound in ObGyn Lis Maternity Hospital, Tel Aviv Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K.","family":"Pooh","sequence":"additional","affiliation":[{"name":"Clinical Research Institute of Fetal Medicine Prenatal Medical Clinic  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Herrera","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Obstetric Department Keralty\u2010Colsanitas Clinic  Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ximenes","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Department Clinica Universitaria Colombia, Clinica Reina Sofia, Keralty, Bogota  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Azumendi","sequence":"additional","affiliation":[{"name":"Ultrasound and Fetal Medicine Unit of Centro Gutenber  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pilu","sequence":"additional","affiliation":[{"name":"U.O. Ostetricia e Medicina dell'Et\u00e0 Prenatale, Dipartimento di Scienze Mediche e Chirurgiche IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-4347","authenticated-orcid":false,"given":"L. J.","family":"Salomon","sequence":"additional","affiliation":[{"name":"LUMIERE Platform, Necker\u2010Enfants Malades Hospital University of Paris  Paris France"},{"name":"Department of Obstetrics, Fetal Medicine and Surgery, Necker\u2010Enfants Malades Hospital, AP\u2010HP University Paris Cit\u00e9  Paris France"},{"name":"URP FETUS 7328, Federation for Research into Innovative Explorations and Therapeutics in Utero University of Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20531"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-024-09821-x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-003-0781-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738020170122601"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0655-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51484"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039804"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11689-010-9059-y"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2107"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22179"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1331"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26187"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.27564"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1937586719887709"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000393"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.00457"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v11.i4.116"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000217"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512534"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6447"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-024-06300-w"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24888"},{"key":"e_1_2_7_24_1","unstructured":"Conf\u00e9rence Nationale d'Echographie Obst\u00e9tricale et Foetale.http:\/\/www.cfef.org\/archives\/bricabrac\/cneof\/recommandationscneof2016.pdf. Accessed October 10 2022."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512953"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2021.033"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1365-8611"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5598"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7383"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.958570"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.61186\/nl.3.1.12"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26129"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61330"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.0146"},{"key":"e_1_2_7_35_1","first-page":"1","article-title":"Parental magnetic resonance imaging for the evaluation of fetuses with brain anomalies","author":"Libzon S","year":"2024","journal-title":"Dev Med Child Neurol"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6382"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6466"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.9396"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20353"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2024.101526"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.70003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T18:57:06Z","timestamp":1763492226000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.70003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,23]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/uog.70003"],"URL":"https:\/\/doi.org\/10.1002\/uog.70003","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,23]]},"assertion":[{"value":"2025-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}