{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:01:49Z","timestamp":1793127709655,"version":"4.5.0"},"reference-count":81,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["02\u2010001\u20102023\u20100141"],"award-info":[{"award-number":["02\u2010001\u20102023\u20100141"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Pre\u2010eclampsia complicates up to 8% of pregnancies and is associated with increased risk of ischemic cardiac and cerebral disease, which may be prevented through management of cardiovascular risk when early disease stages are detected. This meta\u2010analysis aimed to determine the prevalence of clinical and subclinical atherosclerosis in women after pre\u2010eclamptic\n                      <jats:italic>vs<\/jats:italic>\n                      non\u2010pre\u2010eclamptic pregnancy with advancing maternal age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of the literature was conducted in PubMed, Embase and Web of Science for studies reporting on the prevalence of atherosclerosis in women with a previous pre\u2010eclamptic pregnancy and those with a previous uncomplicated pregnancy. Any systemic atherosclerosis documented using ultrasound or computed tomography was included. Random\u2010effects meta\u2010analysis was used to compute the odds ratio (OR) with 95%\u2009CI for the association between pre\u2010eclampsia and the presence of atherosclerosis. Subgroup analysis was conducted according to average maternal age at evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 11 articles were included (13\u2009217 participants). The average maternal age at evaluation ranged from 32 to 60\u2009years. Within this age range, the pooled OR for the presence of atherosclerotic plaque after pre\u2010eclampsia was 1.57 (95%\u2009CI, 1.39\u20131.78). The pooled OR of developing atherosclerotic plaque after a pre\u2010eclamptic\n                      <jats:italic>vs<\/jats:italic>\n                      non\u2010pre\u2010eclamptic pregnancy increased gradually with advancing maternal age. The OR was not significant in the 30\u201339\u2010year\u2010old group (0.64 (95%\u2009CI, 0.10\u20134.15)), but the odds of finding an atherosclerotic plaque were significantly increased after pre\u2010eclamptic pregnancy in the 40\u201349\u2010year\u2010old group (OR, 1.59 (95%\u2009CI, 1.34\u20131.89)) and 50\u201360\u2010year\u2010old group (OR, 2.00 (95%\u2009CI, 1.30\u20133.08)). At any given age, the percentage plaque prevalence in formerly pre\u2010eclamptic women was roughly equal to that seen 10\u2009years later in women with a previous non\u2010pre\u2010eclamptic pregnancy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Women with a previous pre\u2010eclamptic pregnancy exhibit atherosclerosis more frequently and approximately 10\u2009years earlier compared with women with a previous non\u2010pre\u2010eclamptic pregnancy. Targeted primary prevention is required to reduce morbidity and mortality from premature cardiovascular disease in women after pre\u2010eclampsia. \u00a9 2025 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70014","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T20:58:29Z","timestamp":1756673909000},"page":"15-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Atherosclerosis after pre\u2010eclampsia: systematic review and 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