{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:15:17Z","timestamp":1783476917824,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW107\u2010TDU\u2010B\u2010211\u2010123002"],"award-info":[{"award-number":["MOHW107\u2010TDU\u2010B\u2010211\u2010123002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW108\u2010TDU\u2010B\u2010211\u2010133002"],"award-info":[{"award-number":["MOHW108\u2010TDU\u2010B\u2010211\u2010133002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW110\u2010TDU\u2010B\u2010211\u2010124002"],"award-info":[{"award-number":["MOHW110\u2010TDU\u2010B\u2010211\u2010124002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW111\u2010TDU\u2010B\u2010211\u2010134002"],"award-info":[{"award-number":["MOHW111\u2010TDU\u2010B\u2010211\u2010134002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Amniotic fluid volume, measured in terms of the amniotic fluid index (AFI), is used widely in prenatal care to assess fetal health and development. We investigated whether distinct longitudinal AFI trajectories exist during pregnancy and their association with fetal growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This secondary analysis of a randomized controlled trial included singleton pregnancies without pre\u2010existing or gestational diabetes mellitus that received prenatal care at National Taiwan University Hospital in Taipei and its Hsin\u2010Chu Branch in Hsinchu, Taiwan. Ultrasonography was performed at 22\u2009+\u20090 to 24\u2009+\u20096\u2009weeks, 30\u2009+\u20090 to 32\u2009+\u20096\u2009weeks, 35\u2009+\u20090 to 37\u2009+\u20096\u2009weeks and at admission for delivery to measure fetal biometry and AFI. Neonatal anthropometrics and adiposity were measured at delivery. Group\u2010based trajectory modeling was used to identify distinct AFI trajectory patterns during pregnancy. Regression analysis was used to determine differences in fetal and neonatal parameters between AFI trajectory groups, with adjustment for confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 802 pregnancies were included. Two AFI trajectory patterns were identified: one characterized by gradually decreasing AFI during gestation and the other by gradually increasing AFI. On linear regression analysis, compared with the decreasing AFI trajectory, increasing AFI was associated with higher gestational\u2010age\u2010specific\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores for abdominal circumference (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003) and estimated fetal weight (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.036) at 30\u2009+\u20090 to 32\u2009+\u20096\u2009weeks, as well as higher sex\u2010 and gestational\u2010age\u2010specific\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores for birth weight (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.019), neonatal head circumference (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.011), neonatal chest circumference (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.009) and neonatal skinfold thickness (subscapular,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004; triceps,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002), after adjusting for maternal prepregnancy body mass index, history of gestational diabetes mellitus and fasting plasma glucose and triglyceride levels. The adjusted odds ratio of high neonatal adiposity for the increasing\n                      <jats:italic>vs<\/jats:italic>\n                      decreasing AFI trajectory was 2.47 ((95%\u2009CI, 1.21\u20135.11);\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An increasing AFI trajectory during pregnancy was associated with enhanced intrauterine fetal growth, higher birth weight and greater neonatal adiposity. This highlights the potential of AFI trajectory to serve as an indicator of fetal growth alongside fetal biometry. \u00a9 2025 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70018","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T15:00:01Z","timestamp":1756652401000},"page":"589-597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trajectory of serial amniotic fluid index measurements is associated with fetal growth, birth weight and neonatal adiposity"],"prefix":"10.1002","volume":"66","author":[{"given":"S.\u2010C.","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Good Liver Clinics  Taipei 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