{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:29:36Z","timestamp":1793132976646,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the impact of low\u2010dose aspirin (LDA) on placental size and uterine artery pulsatility index (UtA\u2010PI) by analyzing longitudinal changes between the first and second trimesters in pregnancies at high risk for early\u2010onset pre\u2010eclampsia (PE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective observational cohort study of 631 singleton pregnancies. Women at high risk of early\u2010onset PE (delivery \u2264\u200933\u2009+\u20096\u2009weeks) were identified using maternal factors or a multivariate screening protocol and were prescribed LDA. Placental size was assessed using two\u2010 and three\u2010dimensional ultrasonography, and UtA\u2010PI was measured using transabdominal Doppler, with measurements obtained in the first and second trimesters. Differences in placental measurements and UtA\u2010PI between high\u2010risk women receiving LDA and low\u2010risk untreated women were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 631 participants, 53 (8.4%) women were prescribed LDA for the prevention of early\u2010onset PE. Placental size in the first trimester was significantly smaller in the LDA group compared with the untreated group, as exemplified by placental volume (mean\u2009\u00b1\u2009SD, 68.46\u2009\u00b1\u200925.19\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      <jats:italic>vs<\/jats:italic>\n                      76.31\u2009\u00b1\u200923.63\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.022), and this trend persisted into the second trimester. However, no significant differences in placental growth from the first to the second trimester were observed between the groups. UtA\u2010PI was significantly higher in the LDA group in both trimesters, but a greater decrease in UtA\u2010PI multiples of the median values\u00a0between trimesters was noted in these women (mean\u2009\u00b1\u2009SD, \u201314.0\u2009\u00b1\u20090.28%\n                      <jats:italic>vs<\/jats:italic>\n                      \u20134.5\u2009\u00b1\u20090.31%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.021). Perinatal outcomes were similar between the groups, with the exception of a higher rate of Cesarean delivery in the LDA group (38.5%\n                      <jats:italic>vs<\/jats:italic>\n                      21.1%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.008).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Women at high risk for early\u2010onset PE have a smaller placenta and higher UtA\u2010PI in the first and second trimesters. Treatment of high\u2010risk women with LDA did not affect placental growth but was associated with a greater reduction in UtA\u2010PI, suggesting a positive effect of LDA on placental perfusion. These findings provide insight into the mechanism of action of LDA in the prevention of PE. \u00a9 2025 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70095","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T18:00:03Z","timestamp":1758391203000},"page":"641-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5650-1790","authenticated-orcid":false,"given":"C.","family":"Trilla","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau \u2010 IIB Sant Pau, Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Faculty of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS, RD21\/0012\/0001), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Platero","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau \u2010 IIB Sant Pau, Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mora","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Department of Biochemistry Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. N.","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau \u2010 IIB Sant Pau, Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Faculty of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS, RD21\/0012\/0001), Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Alejos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau \u2010 IIB Sant Pau, Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Faculty of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Parra","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau \u2010 IIB Sant Pau, Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Faculty of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-6407","authenticated-orcid":false,"given":"E.","family":"Llurba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau \u2010 IIB Sant Pau, Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Faculty of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona 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