{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T18:58:56Z","timestamp":1763492336305,"version":"3.45.0"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20224BAB216025","20242BAB25446"],"award-info":[{"award-number":["20224BAB216025","20242BAB25446"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260315"],"award-info":[{"award-number":["82260315"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the risk of adverse obstetric and neonatal outcomes in patients with unexplained recurrent implantation failure (uRIF) who had a singleton live birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective cohort study reviewed 49\u2009372 embryo\u2010transfer cycles leading to a singleton live birth at three fertility centers in China between January 2014 and July 2021. Patients were categorized into the uRIF group if they had a history of at least three failed transfers of unknown cause with at least four good\u2010quality embryos, while the control group comprised women who had experienced fewer than three failed implantation cycles. Obstetric and neonatal outcomes were collected via telephone interviews using a standardized questionnaire. Propensity score matching (PSM) and multivariate logistic regression analysis were used to control for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After exclusions, 1244 patients with a history of uRIF and 36\u2009644 controls were included in the study. All baseline characteristics were balanced following PSM, with 1243 patients retained in each group. Compared with the control group, the uRIF group exhibited significantly higher odds of placenta previa (2.7%\n                      <jats:italic>vs<\/jats:italic>\n                      1.4%; adjusted odds ratio (aOR), 2.01 (95%\u2009CI, 1.01\u20134.00)), placental abruption (0.3%\n                      <jats:italic>vs<\/jats:italic>\n                      0%; aOR, 6.51 (95%\u2009CI, 1.57\u201326.91)), Cesarean delivery (76.6%\n                      <jats:italic>vs<\/jats:italic>\n                      71.8%; aOR, 1.27 (95%\u2009CI, 1.06\u20131.53)) and preterm birth (10.1%\n                      <jats:italic>vs<\/jats:italic>\n                      7.3%; aOR, 1.44 (95%\u2009CI, 1.08\u20131.91)). The results remained consistent on sensitivity analysis using prematched data with multivariate adjustment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A history of uRIF was associated with increased risks for placenta previa, placental abruption, Cesarean delivery and preterm birth. While statistically significant, the absolute differences in the rates of these complications were modest and the clinical relevance of our findings should be interpreted with caution. \u00a9 2025 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70099","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T21:23:29Z","timestamp":1758749009000},"page":"649-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of unexplained recurrent implantation failure with obstetric and neonatal outcomes: cohort study of 37\u2009888 singleton live births"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-3986","authenticated-orcid":false,"given":"J.","family":"Huang","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology Nanchang Medical College  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Queen Mary Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology Nanchang Medical College  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Health Management Center &amp; Institute of Health Management, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Queen Mary Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health, Li Ka Shing Faculty of Medicine The University of Hong Kong, Hong Kong Special Administrative Region  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Wenzhou Key Laboratory of Reproduction and Genetics The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3797-3674","authenticated-orcid":false,"given":"L.","family":"Tian","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology Nanchang Medical College  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Xia","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology Nanchang Medical College  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Jiangxi Key Laboratory of Reproductive Health, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology Nanchang Medical College  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.12.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.04.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.08.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0414-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1061766"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2021.103313"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-023-02923-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.5302"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.774646"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2019.05.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43043-022-00097-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.12891\/ceog1792.2015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.09.007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez262"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa086"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-018-2850-x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.02.020"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01133388"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.29209"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.919283"},{"key":"e_1_2_7_24_1","first-page":"378","volume-title":"Towards Reproductive Certainty: Infertility and Genetics Beyond 1999","author":"Gardner DK","year":"1999"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1427922"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2006.09.014"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.05.027"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109552"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.03.022"},{"issue":"1","key":"e_1_2_7_30_1","first-page":"4","article-title":"Technical standard for human assisted reproduction [in chinese]","volume":"15","author":"National Health Commission of China","year":"2004","journal-title":"Chin J Reprod Health"},{"volume-title":"International Classification of Diseases Tenth Revision (ICD\u201010)","year":"2019","author":"World Health Organization","key":"e_1_2_7_31_1"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104779"},{"issue":"2","key":"e_1_2_7_33_1","article-title":"Fresh versus frozen embryo transfers in assisted reproduction","volume":"2","author":"Zaat T","year":"2021","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-024-03041-9"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-024-03042-8"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.09.039"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2024.02.014"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmz146"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.09.039"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.11.1250"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900662R"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15696"},{"issue":"11","key":"e_1_2_7_43_1","first-page":"937","article-title":"Comparison of Doppler ultrasound indices of uterine artery and sub endometrial blood supply in frozen embryo transfer with and without repeated implantation failure: a cross\u2010sectional study","volume":"21","author":"Bayati F","year":"2023","journal-title":"Int J Reprod Biomed"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2023.103822"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126612"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-22-0046"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02093-5"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00440-y"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2022.103657"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03104-6"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-012-9878-8"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14081588"},{"issue":"2","key":"e_1_2_7_53_1","first-page":"120","article-title":"Preterm birth and single nucleotide polymorphisms in cytokine genes","volume":"3","author":"Zhu Q","year":"2014","journal-title":"Transl Pediatr"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802645035"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000468"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1161707"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102840"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2024.05.037"},{"key":"e_1_2_7_59_1","first-page":"51","article-title":"Placental pathology: a review of placenta previa, placental abruption and placenta accreta","volume":"34","author":"Brennan K","year":"2019","journal-title":"Update in Anaesthesia"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.03.027"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2016.1174834"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.5603\/GP.2016.0006"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2015.12.007"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.07.002"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deae040"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoab036"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-01001-5"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.70099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T18:57:13Z","timestamp":1763492233000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.70099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,24]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/uog.70099"],"URL":"https:\/\/doi.org\/10.1002\/uog.70099","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"type":"print","value":"0960-7692"},{"type":"electronic","value":"1469-0705"}],"subject":[],"published":{"date-parts":[[2025,9,24]]},"assertion":[{"value":"2024-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}