{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:02:20Z","timestamp":1793916140527,"version":"4.8.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the Danish prenatal screening program for major fetal congenital heart defects (mCHD), focusing on incidence, detection rates (DRs), pregnancy outcomes and postnatal mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a 5\u2010year nationwide cohort study conducted from January 2018 to December 2022 in Denmark. We included pregnancies suspected of and\/or with a confirmed mCHD and children with a confirmed mCHD, and excluded those who were not screened, false\u2010positive cases and those who emigrated before delivery. The main outcome was the prenatal DR of mCHD. Secondary outcomes were rate of termination of pregnancy, liveborn incidence of mCHD, gestational age at delivery, neonatal surgery rate and postnatal mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from a total of 645 pregnancies and children with mCHD were retrieved from local databases and 602 were included in the final analysis. The prenatal DR of mCHD was 82.6% (497\/602), with one of the highest DRs observed for univentricular heart (99.4% (159\/160)) and the lowest DR for total anomalous pulmonary venous return (7.7% (1\/13)). Termination of pregnancy occurred in 43.4% (261\/602) of cases, with 52.5% (261\/497) of prenatally detected cases opting for termination. The liveborn incidence of mCHD was 0.11% (1.1 per 1000 births), and the median gestational age at delivery was 39\u2009+\u20092\u2009weeks. Surgery was performed in 92.0% (300\/326) of liveborn children, primarily within the first month after birth. The postnatal follow\u2010up time was between 8\u2009months and 5\u2009years, with a mortality rate of 9.8% (32\/326), of which 50.0% occurred neonatally without surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study highlights increased prenatal DRs and a declining liveborn incidence of mCHD in Denmark, underscoring the efficacy of the national screening program and centralized care. Furthermore, the vast majority of patients were treated surgically, and the mortality rate was low. The declining liveborn incidence of mCHD should be monitored and potential causes explored further. \u00a9 2025 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70107","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T21:14:46Z","timestamp":1761081286000},"page":"44-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prenatal detection and outcome of major heart defects in a country with universal screening"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7475-513X","authenticated-orcid":false,"given":"C.","family":"Vedel","sequence":"first","affiliation":[{"name":"Center for Fetal Medicine and Pregnancy, Department of Gynecology, Fertility, and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Genetics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Steensberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8517-4082","authenticated-orcid":false,"given":"O. B.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Center for Fetal Medicine and Pregnancy, Department of Gynecology, Fertility, and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Gj\u00f8rup","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. N.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Munk","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Nyborg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Fetal Medicine Unit Slagelse Hospital  Slagelse Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. W.","family":"Olesen","sequence":"additional","affiliation":[{"name":"Clinic for Fetal Medicine, Department of Gynecology and Obstetrics Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ravn","sequence":"additional","affiliation":[{"name":"Center for Fetal Medicine and Pregnancy, Department of Gynecology, Fertility, and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sperling","sequence":"additional","affiliation":[{"name":"Clinic for Fetal Medicine, Department of Gynecology and Obstetrics Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. G. H.","family":"Thyregod","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Vejlstrup","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. K.","family":"Ekelund","sequence":"additional","affiliation":[{"name":"Center for Fetal Medicine and Pregnancy, Department of Gynecology, Fertility, and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22167"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.2009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.1.67"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.7.916"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951117002682"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307691"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23219"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2023-061949"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.34069"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16953"},{"issue":"1","key":"e_1_2_6_12_1","first-page":"6","article-title":"Detection of critical congenital heart disease among newborns in Argentina through the national surveillance system of congenital heart disease (RENAC)","volume":"120","author":"Groisman B","year":"2022","journal-title":"Arch Argent Pediatr."},{"key":"e_1_2_6_13_1","unstructured":"DFMS.National Guideline on the 2nd\u2010trimester anomaly scan: Danish Fetal Medicine Society.2017Available from:https:\/\/static1.squarespace.com\/static\/5d8120d60fe9717b4299a867\/t\/5dd57d655828035255a60bf3\/1574272361493\/gennemscanningaffostret.pdf."},{"key":"e_1_2_6_14_1","volume-title":"Retningslinjer for Fosterdiagnostik","author":"Sundhedsstyrelsen","year":"2017"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26075"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-024-06529-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1265\/ehpm.23-00358"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-024-02022-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23670"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-020-0791-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512488"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2022.03.022"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.05.017"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-05419-w"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-020-02345-8"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017704"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-053793"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-317581"}],"container-title":["Ultrasound in Obstetrics &amp; 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