{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:54:22Z","timestamp":1780628062009,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The primary aim was to evaluate pre\u2010 and postnatal morphological changes in large simple fetal ovarian cysts following\n                      <jats:italic>in\u2010utero<\/jats:italic>\n                      aspiration compared with expectant management. Secondary aims were to assess postnatal outcome in terms of surgical intervention and to evaluate complications associated with\n                      <jats:italic>in\u2010utero<\/jats:italic>\n                      aspiration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective observational cohort study, conducted between January 2006 and May 2023 in four centers associated with a multidisciplinary prenatal diagnosis center in the Paris area, France. We included all cases with prenatally diagnosed fetal ovarian cysts measuring \u2265\u200930\u2009mm at least once during prenatal ultrasound follow\u2010up and classified as simple at referral. The primary outcome was the occurrence of pre\u2010 and\/or postnatal changes in cyst morphology during ultrasound follow\u2010up suggestive of ovarian hemorrhage or torsion. Postnatal surgery included ovarian oophorectomy or cystectomy performed via laparoscopy or laparotomy. The chi\u2010square test or Fisher's exact test was used, as appropriate, to compare categorical variables between pregnancies that underwent\n                      <jats:italic>in\u2010utero<\/jats:italic>\n                      aspiration\n                      <jats:italic>vs<\/jats:italic>\n                      expectant management, while Wilcoxon's rank\u2010sum test was used to compare continuous variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010five fetal ovarian cysts measuring \u2265\u200930\u2009mm were included: 18 (27.7%) were managed by\n                      <jats:italic>in\u2010utero<\/jats:italic>\n                      ultrasound\u2010guided transabdominal aspiration and 47 (72.3%) were managed expectantly. Gestational age at diagnosis did not differ significantly between groups (median, 33.0 (interquartile range (IQR), 32.0\u201333.3)\u2009weeks\n                      <jats:italic>vs<\/jats:italic>\n                      32.6 (IQR, 31.4\u201333.4)\u2009weeks). The maximum prenatal cyst diameter was greater in cases that underwent\n                      <jats:italic>in\u2010utero<\/jats:italic>\n                      aspiration compared to those managed expectantly (median, 45 (IQR, 40\u201355)\u2009mm vs 39 (IQR, 32\u201345)\u2009mm;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). The median gestational age at\n                      <jats:italic>in\u2010utero<\/jats:italic>\n                      aspiration was 34.2 (IQR, 33.5\u201336.1)\u2009weeks. Pre\u2010 and\/or postnatal morphological changes suggestive of ovarian hemorrhage or torsion were reported in 1\/18 (5.6%) cysts that were aspirated prenatally and 21\/47 (44.7%) cysts managed expectantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003). Postnatal surgery was performed in 1\/18 (5.6%) and 5\/47 (10.6%) cases, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.66). One case of preterm prelabor rupture of membranes occurred following\n                      <jats:italic>in\u2010utero<\/jats:italic>\n                      aspiration at 36.4\u2009weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In\u2010utero<\/jats:italic>\n                      aspiration may help to prevent changes in cyst morphology and related complications in large simple fetal ovarian cysts. Larger prospective studies are needed to confirm this potential benefit; however, definitive evidence would require systematic postnatal surgical exploration in infants with an ovarian cyst, which is not warranted. \u00a9 2025 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70134","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:17:24Z","timestamp":1763119044000},"page":"60-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcome of fetal ovarian cysts following\n                    <i>in\u2010utero<\/i>\n                    aspiration\n                    <i>vs<\/i>\n                    expectant management: multicenter cohort study"],"prefix":"10.1002","volume":"67","author":[{"given":"V.","family":"Peyronnet","sequence":"first","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2013Obst\u00e9trique, H\u00f4pital Louis Mourier, AP\u2010HP  Colombes France"},{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire Prem'Impact  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tudal","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2013Obst\u00e9trique, H\u00f4pital Louis Mourier, AP\u2010HP  Colombes France"},{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire Prem'Impact  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Egloff","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2013Obst\u00e9trique, H\u00f4pital Louis Mourier, AP\u2010HP  Colombes France"},{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire Prem'Impact  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Veluppillai","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2013Obst\u00e9trique, H\u00f4pital Novo  Pontoise France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"No\u00ebl","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2013Obst\u00e9trique, H\u00f4pital d'Eaubonne\u2010Montmorency  Eaubonne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Tordjeman","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2013Obst\u00e9trique, H\u00f4pital d'Argenteuil  Argenteuil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mairovitz","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2013Obst\u00e9trique, Institut Franco\u2010Britannique  Levallois\u2010Perret France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lieng","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2013Obst\u00e9trique, H\u00f4pital Louis Mourier, AP\u2010HP  Colombes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tassin","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2013Obst\u00e9trique, H\u00f4pital Louis Mourier, AP\u2010HP  Colombes France"},{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire Prem'Impact  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8421-9971","authenticated-orcid":false,"given":"O.","family":"Picone","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2013Obst\u00e9trique, H\u00f4pital Louis Mourier, AP\u2010HP  Colombes France"},{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire Prem'Impact  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Inserm IAME 1137  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-7597","authenticated-orcid":false,"given":"L.","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Service de Gyn\u00e9cologie\u2013Obst\u00e9trique, H\u00f4pital Louis Mourier, AP\u2010HP  Colombes France"},{"name":"F\u00e9d\u00e9ration Hospitalo\u2010Universitaire Prem'Impact  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Inserm IAME 1137  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"issue":"5","key":"e_1_2_7_2_1","first-page":"329","article-title":"Fetal ovarian cysts: incidence, diagnosis and management","volume":"49","author":"Bryant AE","year":"2004","journal-title":"J Reprod Med"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1985.13.5.245"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.29421"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26061"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rx.2016.10.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13426"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.3.3043551"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5754"},{"issue":"2","key":"e_1_2_7_10_1","first-page":"139","article-title":"Outcome of ovarian cysts diagnosed on prenatal ultrasound: a systematic review and meta\u2010analysis","volume":"47","author":"Bascietto F","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1771211"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00725.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365146"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(91)90502-K"},{"issue":"24","key":"e_1_2_7_15_1","article-title":"Retrospective review of management of antenatally diagnosed ovarian cysts at the Hospital for Sick Children","volume":"0022","author":"Bloomfield V","year":"2024","journal-title":"J Pediatr Surg"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2022.102352"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5143"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18973"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11122224"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.574300"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005409"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.02.060"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0240-0"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.12371"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2022.935427"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.70134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.70134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.70134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:21:45Z","timestamp":1780608105000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.70134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/uog.70134"],"URL":"https:\/\/doi.org\/10.1002\/uog.70134","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]},"assertion":[{"value":"2025-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}