{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:33:57Z","timestamp":1779910437547,"version":"3.53.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR23\/00004"],"award-info":[{"award-number":["JR23\/00004"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Pre\u2010eclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Early identification of high\u2010risk pregnancies in the first trimester allows preventive treatment with low\u2010dose aspirin. This study aimed to evaluate whether multivariable Gaussian algorithm\u2010based PE screening strategies, with and without placental growth factor (PlGF), are cost beneficial compared with no screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The cost\u2013benefit analysis estimated the total healthcare savings for the two screening strategies compared with no screening, considering both the costs associated with implementing the screening and the savings derived from the number of cases of PE and preterm infants prevented. The analysis was based on real\u2010world data from Catalan maternity centers applied to a cohort of 56\u2009344 pregnancies (annual birth rate in 2023). Univariable sensitivity and best\u2010 and worst\u2010case scenario analyses were also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both screening strategies resulted in cost savings compared with no screening. The Gaussian algorithm without PlGF yielded greater healthcare savings (\u20ac3.38\u2009million) than did the Gaussian algorithm with PlGF (\u20ac3.29\u2009million). However, the addition of PlGF provided greater clinical benefit, preventing a higher number of PE cases. Sensitivity analysis identified PE incidence and preterm birth rates as the primary cost drivers. For the PlGF strategy to be cost beneficial, the PlGF reagent cost per unit should not exceed \u20ac4.31.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Although the Gaussian algorithm without PlGF demonstrated the highest cost savings compared with no screening, incorporating PlGF further improved PE prevention, supporting its broader adoption. A PlGF reagent cost per unit below \u20ac4.31 may make this strategy cost\u2010beneficial, enhancing its clinical implementation. \u00a9 2026 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70155","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T15:44:53Z","timestamp":1767455093000},"page":"162-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cost\u2013benefit analysis of first\u2010trimester pre\u2010eclampsia screening: comparison of multivariable\n                    <scp>Gaussian<\/scp>\n                    algorithm with and without placental growth factor"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8042-8247","authenticated-orcid":false,"given":"E.","family":"Bonacina","sequence":"first","affiliation":[{"name":"Maternal and Fetal Medicine Research group. Vall d'Hebron Research Institute (VHIR), Centres de Recerca de Catalunya (CERCA)  Barcelona Spain"},{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Armengol\u2010Alsina","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Medicine Research group. Vall d'Hebron Research Institute (VHIR), Centres de Recerca de Catalunya (CERCA)  Barcelona Spain"},{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona, Department of Pediatrics Obstetrics and Gynecology, and Preventive Medicine and Public Health  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dalmau","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona, Department of Pediatrics Obstetrics and Gynecology, and Preventive Medicine and Public Health  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Casellas","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona, Department of Pediatrics Obstetrics and Gynecology, and Preventive Medicine and Public Health  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Rold\u00e1n","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Temprado","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Del Barco","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Medicine Research group. Vall d'Hebron Research Institute (VHIR), Centres de Recerca de Catalunya (CERCA)  Barcelona Spain"},{"name":"Maternal Fetal Medicine Unit, Department of Obstetrics Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona, Department of Pediatrics Obstetrics and Gynecology, and Preventive Medicine and Public Health  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Arias","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ferrer\u2010Costa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Maiz","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Medicine Research group. 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