{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:57:04Z","timestamp":1786978624031,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To establish a comprehensive reference range for first\u2010trimester placental three\u2010dimensional (3D) single\u2010vessel fractional moving blood volume (svFMBV) using the OxNNet toolkit, based on values observed in healthy pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study utilized data from the First\u2010trimester Placental Ultrasound (FirstPLUS) study, a longitudinal observational cohort study conducted between March and November 2022 at King's College Hospital, London, UK. Participants underwent 3D ultrasound assessment of the placenta, including power Doppler imaging, during routine first\u2010trimester screening. The OxNNet toolkit was used for automated placental segmentation and 3D\u2010svFMBV calculation. Quality control was performed in three stages to ensure image completeness and segmentation accuracy. Quantile regression and lambda\u2010mu\u2010sigma (LMS) modeling were used to construct reference charts for 3D\u2010svFMBV. Model fit was assessed using the Akaike information criterion, and centile curves were constructed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The final cohort comprised 2547 cases. Visual assessment of histograms and quantile\u2212quantile plots revealed positive skew in 3D\u2010svFMBV determined at five specific locations within the uteroplacental vasculature. LMS modeling provided the best fit for constructing centile charts, with the Box\u2013Cox Power Exponential original distribution used in most cases. The resulting centile charts demonstrated close agreement between predicted and observed centiles, with minimal deviation across all target centiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study provides novel reference ranges for first\u2010trimester placental 3D\u2010svFMBV at five locations within the uteroplacental vasculature. These findings offer a valuable foundation for future research into placental function and pregnancy outcome. \u00a9 2026 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70161","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T18:55:41Z","timestamp":1767812141000},"page":"191-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reference charts for first\u2010trimester placental three\u2010dimensional fractional moving blood volume derived using\n                    <scp>OxNNet<\/scp>"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1609-3654","authenticated-orcid":false,"given":"S.","family":"Mathewlynn","sequence":"first","affiliation":[{"name":"Nuffield Department of Women's and Reproductive Health University of Oxford  Oxford UK"},{"name":"Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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