{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:38:02Z","timestamp":1791722282528,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00064165"],"award-info":[{"award-number":["00064165"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Congenital parvovirus B19 (PB19) infection can lead to severe fetal anemia and hydrops fetalis, necessitating\n                      <jats:italic>in\u2010utero<\/jats:italic>\n                      transfusion (IUT) as a life\u2010saving intervention. This study aimed to identify risk factors associated with unfavorable perinatal outcome following IUT in hydropic fetuses with PB19 infection, with the goal of optimizing transfusion strategies and improving fetal survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective, multicenter, international cohort study was conducted across nine specialized fetal medicine centers in France, Belgium and the Czech Republic. This study included pregnant women with a fetus diagnosed with hydrops due to PB19 infection that underwent at least one IUT for severe fetal anemia between January 2014 and May 2024. Clinical, demographic and procedural data were analyzed. The primary outcome was to identify maternal, fetal, obstetric or IUT\u2010related risk factors associated with adverse fetal or neonatal outcome, defined by a composite criterion of unfavorable outcome that included perinatal mortality and\/or severe and persistent fetal anomalies, including severe fetal brain injury at follow\u2010up. Statistical analysis was conducted using logistic regression models to assess potential risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 84 eligible cases, 78 pregnancies were included in the final analysis. The rate of perinatal survival without severe brain injury was 59.0% (46\/78), while 41.0% (32\/78) of cases had an unfavorable outcome, including 20 (25.6%) cases of stillbirth, nine (11.5%) cases of termination of pregnancy, one (1.3%) case of continuation of pregnancy despite severe prenatal neurological findings and two (2.6%) cases of neonatal death. Notably, a higher fetal hemoglobin (Hb) level (&gt;\u20099.3\u2009g\/dL) after the first or second IUT was significantly associated with a reduced risk of unfavorable outcome (adjusted odds ratio (aOR), 0.6 (95%\u2009CI, 0.4\u20130.8)). A femur length Z\u2010score of &lt;\u2009\u22122 was associated with unfavorable outcome (aOR, 5.4 (95%\u2009CI, 1.3\u201327.0)). Transplacental\n                      <jats:italic>vs<\/jats:italic>\n                      transamniotic funicular puncture was not significantly associated with perinatal survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IUT remains a cornerstone intervention for managing severe fetal anemia caused by PB19 infection; however, rates of perinatal loss continue to be substantial, especially in the presence of severe hydrops. Achieving higher post\u2010transfusion Hb levels appears to be an important factor in improving survival outcomes for hydropic fetuses with PB19 infection. \u00a9 2026 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70174","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T05:27:48Z","timestamp":1770096468000},"page":"312-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Perinatal outcomes following\n                    <i>in\u2010utero<\/i>\n                    transfusion for hydrops fetalis associated with parvovirus\n                    <scp>B19<\/scp>\n                    infection"],"prefix":"10.1002","volume":"67","author":[{"given":"M.","family":"Parent","sequence":"first","affiliation":[{"name":"Division of Obstetrics and Gynecology, Antoine B\u00e9cl\u00e8re Hospital Paris Saclay University Hospitals, AP\u2010HP  Clamart France"},{"name":"Fetal Medicine Department, Armand Trousseau Hospital Sorbonne University, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Maurice","sequence":"additional","affiliation":[{"name":"Fetal Medicine Department, Armand Trousseau Hospital Sorbonne University, AP\u2010HP  Paris France"},{"name":"National Reference Center for Perinatal Hemobiology (CNRHP), Clinic Unit, Armand Trousseau Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Van den Eede","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mattern","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Antoine B\u00e9cl\u00e8re Hospital Paris Saclay University Hospitals, AP\u2010HP  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Jeanne de Flandre Hospital Lille University Hospitals  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Paret","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Paul Viguier Hospital Toulouse University Hospitals  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1947-1736","authenticated-orcid":false,"given":"G.","family":"Dumery","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Bic\u00eatre Hospital Paris Saclay University Hospitals, AP\u2010HP  Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Badr","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Brugmann, Universit\u00e9 Libre de Bruxelles, Vrije Universiteit Brussel  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-4684","authenticated-orcid":false,"given":"R.","family":"Devlieger","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2903-5026","authenticated-orcid":false,"given":"P.","family":"Calda","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Neonatology, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Quibel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Poissy\u2010Saint Germain Hospital  Poissy France"},{"name":"Paris Saclay University, UVSQ, Inserm, Team U1018, Clinical Epidemiology, CESP  Montigny\u2010le\u2010Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Vauloup\u2010Fellous","sequence":"additional","affiliation":[{"name":"Paris Saclay University, INSERM U1184, CEA, Center for Immunology of Viral, Auto\u2010immune, Hematological and Bacterial diseases (IMVA\u2010HB\/IDMIT)  Fontenay\u2010aux\u2010Roses France"},{"name":"Division of Virology, Laboratoire de Biologie M\u00e9dicale de R\u00e9f\u00e9rence \u201cVirus et P\u00e9rinatalit\u00e9\u201d \u201cPaul Brousse\u201d Hospital Paris Saclay University Hospitals, AP\u2010HP  Villejuif France"},{"name":"Groupe de Recherche sur les Infections pendant la Grossesse (GRIG)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Benachi","sequence":"additional","affiliation":[{"name":"Division of 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