{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:10:11Z","timestamp":1778937011684,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To estimate the residual risk of maternal\u2013fetal transmission after primary cytomegalovirus (CMV) infection in the periconceptional period or the first trimester in women treated with valacyclovir, and to assess whether the presence of glycoprotein B2 (gB2)\u2010specific immunoglobulin (Ig)\u2010G antibodies on immunoblot analysis refines fetal risk prediction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective single\u2010center study conducted at University Hospital T\u00fcbingen, T\u00fcbingen, Germany, between October 2023 and June 2025. Pregnant women with a primary CMV infection diagnosed &lt;\u200914\u2009weeks' gestation who received valacyclovir (8\u2009g\/day) were included in the study. The diagnosis of a recent primary CMV infection was based on maternal serology results, specifically positive anti\u2010CMV\u2010immunoglobulin (Ig)\u2010G and \u2010IgM levels, and low or intermediate IgG avidity. Additionally, prior to initiation of valacyclovir treatment, the presence or absence of glycoprotein B (gB)2\u2010specific IgG antibodies was determined using a commercial line immunoblot. The primary outcome was maternal\u2013fetal transmission of CMV detected at the time of second\u2010trimester amniocentesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010five women met the inclusion criteria, including 47 with periconceptional and 38 with first\u2010trimester maternal CMV infection. Median maternal and gestational age at the time of diagnosis of primary maternal CMV infection were 33.1 (interquartile range (IQR), 29.9\u201334.9)\u2009years and 7.4 (IQR, 6.4\u20138.9)\u2009weeks, respectively. Amniocentesis was performed at a median gestational age of 20.6 (IQR, 20.1\u201321.0)\u2009weeks. Overall, maternal\u2013fetal transmission was detected in 7\/85 (8.2%) cases at the time of amniocentesis. All CMV transmissions occurred in women without gB2\u2010specific IgG antibodies (7\/55 (12.7%)), while no transmissions occurred in those with gB2\u2010specific IgG antibodies (0\/30 (0%)) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.048).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In women with a primary CMV infection treated with valacyclovir, the presence of gB2\u2010specific IgG antibodies on immunoblot analysis identifies a subgroup with a low residual risk of maternal\u2013fetal transmission. Incorporating gB2\u2010specific IgG antibodies status into risk stratification may improve patient counseling and clinical decision\u2010making. \u00a9 2026 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70206","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T09:32:17Z","timestamp":1774863137000},"page":"455-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive value of\n                    <scp>gB2<\/scp>\n                    antibodies for maternal\u2013fetal transmission after primary cytomegalovirus infection treated with valacyclovir"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-5143","authenticated-orcid":false,"given":"K. O.","family":"Kagan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L.","family":"Bissinger","sequence":"additional","affiliation":[{"name":"Institute of Medical Virology and Epidemiology of Viral Diseases University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sonek","sequence":"additional","affiliation":[{"name":"Fetal Medicine Foundation USA  Dayton OH USA"},{"name":"Division of Maternal Fetal Medicine Wright State University  Dayton OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hoopmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-267X","authenticated-orcid":false,"given":"Y.","family":"Ville","sequence":"additional","affiliation":[{"name":"EA Fetus, Paris Descartes University, University of Paris  Paris France"},{"name":"Department of Obstetrics, Fetal Medicine and Surgery, Necker\u2013Enfants Malades Hospital, AP\u2013HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Enders","sequence":"additional","affiliation":[{"name":"Laboratory Prof. Dr. G. Enders and Colleagues, MVZ  Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17966"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30143-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.100892"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.10.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4380-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21991"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.05.038"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26136"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.07.022"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2018.09.013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23471"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.09.015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/175.3.533"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2096"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.10.3689-3693.2002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23596"},{"key":"e_1_2_7_18_1","unstructured":"AWMF Guideline.Praevention\u2010Diagnostik\u2010Therapie\u2010CMV\u2010Infektion\u2010Schwangere\u2010konnatalen\u2010CMV\u2010Infektion\u2010Neugeborene\u2010Kinder_2025\u201004 (1).pdf.AWMF Registernummer 093\/003.https:\/\/register.awmf.org\/assets\/guidelines\/093\u2010003l_S2k_Praevention\u2010Diagnostik\u2010Therapie\u2010CMV\u2010Infektion\u2010Schwangere\u2010konnatalen\u2010CMV\u2010Infektion\u2010Neugeborene\u2010Kinder_2025\u201004.pdfLast accessed: 16 November 2025."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.03.006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0147-9571(91)90124-V"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2025.07.050"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.70206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.70206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.70206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:37:00Z","timestamp":1778935020000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.70206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/uog.70206"],"URL":"https:\/\/doi.org\/10.1002\/uog.70206","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]},"assertion":[{"value":"2025-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}