{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:26:00Z","timestamp":1787379960107,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["10210746"],"award-info":[{"award-number":["10210746"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate maternal cardiac adaptation during pregnancy by comparing longitudinal hemodynamic profiles between women identified as high risk for preterm pre\u2010eclampsia (PE) who subsequently developed preterm PE, term PE or remained unaffected, as well as low\u2010risk women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a prospective longitudinal study of 1078 Chinese women with a singleton pregnancy who were enrolled in a first\u2010trimester screen\u2010and\u2010prevent program for preterm PE at the Prince of Wales Hospital, Hong Kong SAR, China, between January 2020 and June 2024. Participants were classified as high or low risk for preterm PE based on the Fetal Medicine Foundation first\u2010trimester combined test. Participants were followed up at 12\u2009+\u20090 to 15\u2009+\u20096\u2009weeks' gestation, 20\u2009+\u20090 to 24\u2009+\u20096\u2009weeks and 30\u2009+\u20090 to 37\u2009+\u20096\u2009weeks to measure hemodynamic variables, including heart rate (HR), stroke volume (SV), cardiac output (CO), systemic vascular resistance (SVR) and mean arterial pressure (MAP). Participants were categorized into four groups according to risk status for preterm PE and subsequent development of PE: low risk who did not develop PE (Group\u20091,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009407); high risk who did not develop PE (Group\u20092,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009598); high risk who developed term PE (Group\u20093,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929); and high risk who developed preterm PE (Group\u20094,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200944). Hemodynamic variables were log\n                      <jats:sub>10<\/jats:sub>\n                      transformed and analyzed using linear mixed\u2010effects models, adjusting for maternal characteristics and clinical visits. Estimated marginal means of log\n                      <jats:sub>10<\/jats:sub>\n                      \u2010transformed values for hemodynamic variables were compared between the groups throughout pregnancy and at each clinical\u00a0visit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with Group\u20091, all high\u2010risk groups exhibited lower SV and CO and higher SVR and MAP throughout pregnancy (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05), while HR was significantly elevated in Group\u20092 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Compared with Group\u20092, Group\u20094 had lower HR, SV and CO and higher SVR and MAP throughout pregnancy (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). In contrast, Group\u20093 showed no significant differences in HR, SV, CO and SVR compared with Group\u20092 (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05), although there was an increase in MAP from midgestation onwards (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Compared with Group\u20093, Group\u20094 exhibited lower CO and higher SVR and MAP throughout pregnancy (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Compared with low\u2010risk women who do not develop PE, high\u2010risk women with or without preterm or term PE exhibit distinct cardiac maladaptation profiles from early to late gestation. These findings offer insight into the different pathophysiological mechanisms underlying PE subtypes and should inform risk stratification. \u00a9 2026 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70215","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:45:53Z","timestamp":1775882753000},"page":"623-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal maternal hemodynamics in high\u2010risk pregnancies with different subtypes of pre\u2010eclampsia"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0769-8974","authenticated-orcid":false,"given":"J.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1219-6026","authenticated-orcid":false,"given":"X.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanchong Central Hospital The Second Clinical Medical College of North Sichuan Medical University  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Nguyen\u2010Hoang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"},{"name":"Fetal Medicine Centre, Tam Anh HCMC General Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S. T.","family":"Tai","sequence":"additional","affiliation":[{"name":"School of Nursing Tung Wah College  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. S.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. H.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2733-8939","authenticated-orcid":false,"given":"H. H. 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