{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:51:59Z","timestamp":1791129119021,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:00:00Z","timestamp":1777680000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fetal complete atrioventricular block (f\u2010CAVB) with ventricular bradycardia of \u2264\u200955\u2009bpm is associated with increased perinatal mortality. With the goal of increasing perinatal survival of f\u2010CAVB cases, we initiated a delivery room protocol to increase fetal heart rate (HR) and cardiac output using intramuscular and intravenous epinephrine given immediately before Cesarean delivery and prior to umbilical cord clamping. We tested the safety and efficacy of this concept of \u2018chronotropic rescue\u2019 in the delivery management of seven fetuses with f\u2010CAVB meeting fetal HR criteria of \u2264\u200955\u2009bpm in the 12\u2009h prior to delivery. The combination of exogenous epinephrine and delayed umbilical cord clamping increased neonatal HR and stabilized the neonates who received an epicardial pacemaker &lt;\u200924\u2009h to 5\u2009days after delivery. Based on the findings of this Case Series, chronotropic rescue with delayed umbilical cord clamping may improve survival and should be considered in the perinatal management of high\u2010risk f\u2010CAVB cases with very low fetal HR. \u00a9 2026 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>","DOI":"10.1002\/uog.70221","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T23:09:51Z","timestamp":1777763391000},"page":"152-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neonatal outcomes following chronotropic rescue and delayed umbilical cord clamping in fetal complete atrioventricular block with low heart rate"],"prefix":"10.1002","volume":"68","author":[{"given":"C.","family":"Londono\u2010Obregon","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"},{"name":"The Colorado Fetal Care Center, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"},{"name":"The Colorado Fetal Care Center, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. L.","family":"Galan","sequence":"additional","affiliation":[{"name":"The Colorado Fetal Care Center, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"},{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"},{"name":"Department of Pediatrics, Division of Neonatology, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"Kinsella","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"},{"name":"Department of Pediatrics, Division of Neonatology, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M.","family":"Bucholz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"},{"name":"The Colorado Fetal Care Center, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Behrendt","sequence":"additional","affiliation":[{"name":"The Colorado Fetal Care Center, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"},{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Zaretsky","sequence":"additional","affiliation":[{"name":"The Colorado Fetal Care Center, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"},{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Kaizer","sequence":"additional","affiliation":[{"name":"Biostatistics and Informatics, Colorado School of Public Health University of Colorado  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Skaggs\u00a0School of Pharmacy and Pharmaceutical Sciences  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9085-0882","authenticated-orcid":false,"given":"B. F.","family":"Cuneo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"},{"name":"The Colorado Fetal Care Center, Children's Hospital Colorado University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2025.05.013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001367"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000475815"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13109"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.250084"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270926"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-305703"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.70221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.70221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.70221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:59:01Z","timestamp":1791125941000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.70221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,2]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/uog.70221"],"URL":"https:\/\/doi.org\/10.1002\/uog.70221","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,2]]},"assertion":[{"value":"2025-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}