{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:00:30Z","timestamp":1781650830534,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet & Gyne"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n Cytomegalovirus (CMV) is the leading cause of congenital infectious neurosensory impairment. We aimed to present national epidemiological data on maternal CMV infection during pregnancy in France, focusing in particular on primary infection in the periconceptional period or first trimester, and to assess the impact of changes in screening practices and clinical management of affected pregnant women and their newborns.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this retrospective, multicenter study, we retrieved data from the electronic database of the French National Reference Center for Herpesviruses from cases of maternal CMV infection diagnosed during pregnancy between January 2017 and December 2023, with known neonatal infection status (infected or non\u2010infected) at birth. Maternal, fetal and neonatal data in cases with maternal primary infection during the periconceptional period or first trimester were compared between the periods before and after publication of a pivotal randomized controlled trial (RCT) in September 2020 that demonstrated that valacyclovir reduced vertical transmission by two\u2010thirds when administered to women with first\u2010trimester primary CMV infection.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 451 documented cases of maternal CMV infection during pregnancy with known fetal\/newborn CMV status, there were 220 pregnancies (222 fetuses) with periconceptional or first\u2010trimester primary maternal infection (PI), among which maternal\u2013fetal transmission occurred in 176 (79.3%). Compared with the period from 2017 to 2020, in the period from 2021 to 2023 there was a significant increase in both systematic CMV screening (from 22.0% to 40.0%;\n P<\/jats:italic>\n \u2009=\u20090.001) and maternal requests for testing (from 0% to 4.2%;\n P<\/jats:italic>\n \u2009=\u20090.02). Among cases of maternal infection during the periconceptional period or in the first trimester, antiviral therapy (generally valacyclovir) was administered more frequently in the period from 2021 to 2023 (27.7%\n vs<\/jats:italic>\n 59.8%;\n P<\/jats:italic>\n \u2009<\u20090.0001). The overall rate of termination of pregnancy (TOP) for early maternal CMV\u2010PI was 20.7% (40\/193 with known pregnancy outcome), with significantly fewer TOPs being performed in the period from 2021 to 2023 (25.9%\n vs<\/jats:italic>\n 13.0%;\n P<\/jats:italic>\n \u2009=\u20090.03). Notably, women who did not receive valacyclovir treatment had higher rates of TOP overall compared with women who had received valacyclovir (22.1%\n vs<\/jats:italic>\n 8.1%;\n P<\/jats:italic>\n \u2009=\u20090.01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Congenital CMV infection is a major public health problem. Despite the lack of national guidelines for systematic maternal CMV screening until mid\u20102025, the uptake of maternal CMV screening and preventive treatment increased significantly in France after publication of the pivotal RCT in 2020, apparently without an associated rise in the rate of TOP. These findings support the safety and potential benefits of offering CMV serological testing during pregnancy, particularly in the context of evidence\u2010based therapeutic options. \u00a9 2026 The Author(s).\n Ultrasound in Obstetrics & Gynecology<\/jats:italic>\n published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/uog.70223","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:17:45Z","timestamp":1777879065000},"page":"756-763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changing trends in prenatal screening and treatment of cytomegalovirus infection in\n France<\/scp>\n : 7\u2010year national cohort study (2017\u20132023)"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7558-0175","authenticated-orcid":false,"given":"P.","family":"Coste\u2010Mazeau","sequence":"first","affiliation":[{"name":"University of Limoges, Inserm, CHU Limoges, RESINFIT U 1092 Limoges France"},{"name":"National Reference Center for Herpesviruses, Virology Department CHU Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ribot","sequence":"additional","affiliation":[{"name":"National Reference Center for Herpesviruses, Virology Department CHU Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hantz","sequence":"additional","affiliation":[{"name":"University of Limoges, Inserm, CHU Limoges, RESINFIT U 1092 Limoges France"},{"name":"National Reference Center for Herpesviruses, Virology Department CHU Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ville","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, URP 7328 FETUS Paris France"},{"name":"Obstetrics, Fetal Medicine Surgery and Imaging Unit, H\u00f4pital Necker\u2010Enfants Malades, GHU Paris Centre, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7513-7894","authenticated-orcid":false,"given":"M.","family":"Leruez\u2010Ville","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, URP 7328 FETUS Paris France"},{"name":"Virology Laboratory, National Reference Center for Herpesviruses associated laboratory, H\u00f4pital Necker\u2010Enfants Malades, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9787-1421","authenticated-orcid":false,"given":"S.","family":"Alain","sequence":"additional","affiliation":[{"name":"University of Limoges, Inserm, CHU Limoges, RESINFIT U 1092 Limoges France"},{"name":"National Reference Center for Herpesviruses, Virology Department CHU Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the French Congenital Infection database group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.banm.2019.10.020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.535"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00013"},{"key":"e_1_2_7_5_1","first-page":"254","article-title":"Infectious diseases screening during pregnancy: results from\u2009the\u2009ELFE survey in\u2009maternity units, mainland France, 2011","volume":"15","author":"Richaud\u2010Eyraud E","year":"2015","journal-title":"Bull Epid\u00e9miol Hebdomadaire"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02139.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31868-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26039"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23685"},{"issue":"23","key":"e_1_2_7_10_1","article-title":"The effect of valacyclovir on secondary prevention of congenital cytomegalovirus infection, following primary maternal infection acquired periconceptionally or in the first trimester of pregnancy. An individual patient data meta\u2010analysis","volume":"0002","author":"Chatzakis C","year":"2023","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.100892"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30143-3"},{"key":"e_1_2_7_13_1","unstructured":"HCSP.D\u00e9pistage syst\u00e9matique de l'infection \u00e0 cytom\u00e9galovirus pendant la grossesse. 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