{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:26:01Z","timestamp":1787379961231,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The placenta plays a crucial role in fetal development, yet normal placental volumetric growth trajectories remain poorly characterized, as most studies focus on pathological pregnancies or limited gestational\u2010age (GA) ranges. We aimed to establish magnetic reference imaging (MRI)\u2010based normative reference curves for placental volume (PV) and the placental\u2010to\u2010fetal\u2010volume ratio (PFR) between 16 and 36\u2009weeks' gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center, prospective study conducted as part of the \u2018LUMIERE on the Fetus\u2019 project included healthy pregnant women with a low\u2010risk, singleton, 16\u201336\u2010week fetus evaluated between December 2021 and June 2022. Additional participants with MRI data available at 16\u2009weeks were recruited between January 2023 and October 2025. MRI was performed using a standardized protocol, and placental and fetal volumes were segmented using three\u2010dimensional imaging software. Mean fetal body volume across 16\u201336\u2009weeks was derived from our previously published normative MRI\u2010based dataset obtained from the same cohort. Mean PV and PFR were calculated for each week of gestation. PV growth across gestation was modeled using logarithmic regression, while PFR growth was modeled using a quadratic term, and percentile curves were generated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study cohort comprised 265 MRI datasets from 247 healthy pregnant women with a singleton fetus. Mean PV increased from 149\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      at 16\u2009weeks to 890\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      at 36\u2009weeks, following the function: PV(GA)\u2009=\u2009(911.3\u2009\u00d7\u2009ln(GA))\u2009\u2212\u20092375.7, where GA is in weeks. Over the same period, fetal body volume increased 22\u2010fold, leading to a progressive decline in PFR. Specifically, mean PFR decreased from 1.22 at 16\u2009weeks to 0.31 at 36\u2009weeks, confirming its downward trajectory as fetal growth progresses. The relationship between PFR and GA was modeled using the quadratic function: PFR(GA)\u2009=\u20094.03\u2009\u2212\u2009(0.215\u2009\u00d7\u2009GA)\u2009+\u2009(0.00313\u2009\u00d7\u2009GA\n                      <jats:sup>2<\/jats:sup>\n                      ), where GA is in weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study establishes MRI\u2010based normative percentile curves for PV and PFR, from 16 to 36\u2009weeks' gestation, confirming the physiological decline in PFR with advancing gestation. These benchmarks may aid in detecting placental dysfunction and characterizing fetal growth restriction. Further validation is needed in pathological and multiple pregnancies. \u00a9 2026 International Society of Ultrasound in Obstetrics and Gynecology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70226","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:31:17Z","timestamp":1776324677000},"page":"657-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Normative ranges of\n                    <scp>MRI<\/scp>\n                    \u2010based placental volume and placental\u2010to\u2010fetal\u2010volume ratio at 16\u201336\u2009weeks: prospective study"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2061-0856","authenticated-orcid":false,"given":"A.","family":"Bouachba","sequence":"first","affiliation":[{"name":"SOFFOET, Soci\u00e9t\u00e9 Fran\u00e7aise de F\u0153topathologie  Paris France"},{"name":"IMAGE Mediterranean Institute of Medical Imaging Applied to Gynecology, Pregnancy and Childhood  Marseille France"},{"name":"LUMIERE, URP 7328 FETUS, Necker Sick Children Hospital, AP\u2010HP Paris University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bartin","sequence":"additional","affiliation":[{"name":"LUMIERE, URP 7328 FETUS, Necker Sick Children Hospital, AP\u2010HP Paris University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Virfollet","sequence":"additional","affiliation":[{"name":"LUMIERE, URP 7328 FETUS, Necker Sick Children Hospital, AP\u2010HP Paris University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1074-8848","authenticated-orcid":false,"given":"J.","family":"De Jesus Neves","sequence":"additional","affiliation":[{"name":"IMAGE Mediterranean Institute of Medical Imaging Applied to Gynecology, Pregnancy and Childhood  Marseille France"},{"name":"LUMIERE, URP 7328 FETUS, Necker Sick Children Hospital, AP\u2010HP Paris University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bussi\u00e8res","sequence":"additional","affiliation":[{"name":"LUMIERE, URP 7328 FETUS, Necker Sick Children Hospital, AP\u2010HP Paris University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Gr\u00e9vent","sequence":"additional","affiliation":[{"name":"LUMIERE, URP 7328 FETUS, Necker Sick Children Hospital, AP\u2010HP Paris University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Salomon","sequence":"additional","affiliation":[{"name":"LUMIERE, URP 7328 FETUS, Necker Sick Children Hospital, AP\u2010HP Paris University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gorincour","sequence":"additional","affiliation":[{"name":"IMAGE Mediterranean Institute of Medical Imaging Applied to Gynecology, Pregnancy and Childhood  Marseille France"},{"name":"LUMIERE, URP 7328 FETUS, Necker Sick Children Hospital, AP\u2010HP Paris University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318253d3df"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22441"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.11.117"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615285"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb09023.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2022.2157256"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2023.02.009"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-018-4213-x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20272"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70324-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-7657-3_19"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.29234"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.86.2.420"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"key":"e_1_2_6_16_1","unstructured":"Posit.Posit. Accessed March 9 2025.https:\/\/www.posit.co\/"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20345"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/b97636"},{"key":"e_1_2_6_19_1","unstructured":"Model Selection and Multimodel Inference: A Practical Information\u2010Theoretic Approach|Springer Nature Link (formerly SpringerLink). Accessed January 14 2026.https:\/\/link.springer.com\/book\/10.1007\/b97636"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP090442"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030568"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.173013"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22794"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14115"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13006.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11010030.x"},{"issue":"1147","key":"e_1_2_6_27_1","article-title":"Artificial intelligence applied to fetal MRI: a scoping review of current research","volume":"96","author":"Meshaka R","year":"2023","journal-title":"Br J Radiol"},{"key":"e_1_2_6_28_1","first-page":"2599","article-title":"Fetal MRI synthesis via balanced auto\u2010encoder based generative adversarial networks","volume":"2018","author":"Torrents\u2010Barrena J","year":"2018","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2015.01.004"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.70226","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.70226","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.70226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:20:04Z","timestamp":1787379604000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.70226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/uog.70226"],"URL":"https:\/\/doi.org\/10.1002\/uog.70226","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"assertion":[{"value":"2025-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}