{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:00:14Z","timestamp":1781650814244,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF23OC0085372"],"award-info":[{"award-number":["NNF23OC0085372"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015223","name":"Danish Diabetes and Endocrine Academy","doi-asserted-by":"publisher","award":["NNF22SA0079901"],"award-info":[{"award-number":["NNF22SA0079901"]}],"id":[{"id":"10.13039\/100015223","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the incidence of pre\u2010eclampsia (PE) and the predictive performance of the Fetal Medicine Foundation (FMF) first\u2010trimester PE screening algorithm across pregnancies conceived using assisted reproductive technology (ART), after ovulation induction (OI) and through spontaneous conception (SC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective multicenter study included women with a singleton pregnancy undergoing routine combined first\u2010trimester screening for aneuploidies at six Danish university hospitals from May 2019 to December 2020. Data on maternal characteristics, including mode of conception, medical history, mean arterial pressure (MAP), uterine artery pulsatility index, serum pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) and placental growth factor, were collected to calculate an individual risk of PE using the FMF algorithm, without any clinical intervention based on the risk estimate. Obstetric outcomes, including PE diagnosis, were collected from the national birth registry. Women were categorized into three conception groups: ART, OI and SC. The ART group was further subdivided into ART using frozen embryo transfer (FET), fresh embryo transfer (fresh ET) or oocyte donation (OD). Detection rates (DRs) of the FMF algorithm were calculated using the risk cut\u2010off that defined a screen\u2010positive rate of 10% in the overall population and compared across conception groups. Differences in screen\u2010positive rates and individual risk markers were further investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 8157 women included in the study, 535 conceived using ART, 235 after OI and 7387 through SC. The incidence of PE was highest in the ART group (7.3%) compared with the OI (5.1%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.34) and SC (3.4%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) groups. Among ART subgroups, the incidence of PE was 8.3% in FET, 6.4% in fresh ET and 12.3% in OD pregnancies (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05). However, the distribution of preterm\n                      <jats:italic>vs<\/jats:italic>\n                      term PE differed significantly across ART subgroups, with FET pregnancies showing a larger proportion of term PE (preterm, 11.1%; term, 88.9%) and OD pregnancies a larger proportion of preterm PE (preterm, 57.1%; term, 42.9%) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03). The DR for preterm PE was 81.8% (95%\u2009CI, 48.2\u201397.7%) in ART pregnancies and 64.3% (95%\u2009CI, 48.0\u201378.4%) in SC pregnancies (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.47). For overall PE, the DR was significantly higher in ART pregnancies (69.2% (95%\u2009CI, 52.4\u201383.0%)) than in SC pregnancies (35.7% (95%\u2009CI, 29.8\u201342.0%)) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). There was no significant difference in DRs for overall PE across ART subgroups. The corresponding screen\u2010positive rates for PE varied significantly across conception groups: 22.8% in ART, 14.5% in OI and 8.9% in SC pregnancies (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01 for all). Significant differences in individual risk markers were observed across the ART subgroups, with higher MAP in OD pregnancies and higher PAPP\u2010A in FET pregnancies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A higher incidence of PE was observed in women who conceived using ART and notable differences in the distribution of preterm and term PE were observed among the ART subgroups. The FMF first\u2010trimester PE screening algorithm showed high DRs across all conception groups. However, differences in screen\u2010positive rates and individual risk marker profiles suggest that the incorporation of ART\u2010subgroup\u2010specific adjustments could improve the predictive performance of the model in ART pregnancies, and underscore the need for tailored clinical management and patient communication. Given the high incidence of term PE in FET pregnancies, alternative interventions to acetylsalicylic acid may be necessary, given that this primarily prevents preterm PE. \u00a9 2026 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70244","type":"journal-article","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T09:34:13Z","timestamp":1779615253000},"page":"806-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive performance of Fetal Medicine Foundation first\u2010trimester screening algorithm for pre\u2010eclampsia according to conception mode"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3623-7635","authenticated-orcid":false,"given":"A. 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L.","family":"Kjaer","sequence":"first","affiliation":[{"name":"The Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics Copenhagen University Hospital\u00a0\u2013\u00a0Rigshospitalet  Copenhagen Denmark"},{"name":"Center of Fetal Medicine and Pregnancy, Department of Gynaecology, Fertility and Obstetrics Copenhagen University Hospital\u00a0\u2013\u00a0Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9353-8958","authenticated-orcid":false,"given":"I.","family":"Riishede","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine and Pregnancy, Department of Gynaecology, Fertility and Obstetrics Copenhagen University Hospital\u00a0\u2013\u00a0Rigshospitalet  Copenhagen Denmark"},{"name":"Center of Fetal Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9080-3389","authenticated-orcid":false,"given":"L.","family":"Rode","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital\u00a0\u2013\u00a0Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-672X","authenticated-orcid":false,"given":"R. B.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Pediatrics and Adolescent Medicine Copenhagen University Hospital\u00a0\u2013\u00a0Herlev  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Pihl","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynecology Copenhagen University Hospital\u00a0\u2013\u00a0Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sperling","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Department of Obstetrics and Gynecology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-590X","authenticated-orcid":false,"given":"M.","family":"Overgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Clinical Biochemistry Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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