{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T22:25:04Z","timestamp":1787091904601,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>First, to evaluate whether the ratio of soluble fms\u2010like tyrosine kinase\u20101 to placental growth factor (sFlt\u20101\/PlGF) is associated with hemodynamic changes in ophthalmic artery (OA) Doppler in near\u2010term pregnancy. Second, to assess the performance of OA Doppler to rule in and rule out angiogenic factor imbalance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross\u2010sectional cohort study nested within the PE37 randomized controlled trial, involving nulliparous women recruited between January 2023 and January 2025 who underwent sFlt\u20101\/PlGF ratio measurement between 35\u2009+\u20090 and 36\u2009+\u20096\u2009weeks' gestation. We included a subsample of women who underwent OA Doppler evaluation, including measurement of OA peak systolic velocity (PSV) ratio and OA pulsatility index (PI), as well as assessment of mean arterial pressure (MAP) and mean uterine artery (UtA) PI. The operator was blinded to sFlt\u20101\/PlGF ratio values. Trends in median values of OA and maternal\u2013fetal Doppler parameters across sFlt\u20101\/PlGF tertiles were analyzed using the Jonckheere\u2013Terpstra test and quantile regression, adjusting for maternal body mass index, age and smoking status. The predictive performance of the OA\u2010PSV ratio for sFlt\u20101\/PlGF ratio\u2009\u2265\u200938 was evaluated using receiver\u2010operating\u2010characteristics\u2010curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 203 women, of whom 62, 71 and 70 were in the lowest, middle and highest tertiles of the sFlt\u20101\/PlGF ratio, respectively. With increasing sFlt\u20101\/PlGF ratio tertile, there was a significant increase in the OA\u2010PSV ratio (median, 0.45 (interquartile range (IQR), 0.39\u20130.53)\n                      <jats:italic>vs<\/jats:italic>\n                      0.48 (IQR, 0.41\u20130.58)\n                      <jats:italic>vs<\/jats:italic>\n                      0.59 (IQR, 0.50\u20130.66); adjusted\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u20090.001), a significant decrease in OA\u2010PI (median, 2.20 (IQR, 1.92\u20132.61)\n                      <jats:italic>vs<\/jats:italic>\n                      2.13 (IQR, 1.86\u20132.37)\n                      <jats:italic>vs<\/jats:italic>\n                      1.86 (IQR, 1.60\u20132.26); adjusted\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.031) and a significant increase in MAP (median, 87.0 (IQR, 82.7\u201392.0)\u2009mmHg\n                      <jats:italic>vs<\/jats:italic>\n                      88.7 (IQR, 83.7\u201393.7)\u2009mmHg\u00a0\n                      <jats:italic>vs<\/jats:italic>\n                      94.7 (IQR, 89.3\u2013100.0)\u2009mmHg; adjusted\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In contrast, no significant trend was observed in mean UtA\u2010PI across sFlt\u20101\/PlGF ratio tertiles. Among those individuals with an OA\u2010PSV ratio\u2009&lt;\u20090.61, 90.5% truly had a sFlt\u20101\/PlGF ratio\u2009&lt;\u200938, at a 15% false\u2010positive rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study provides new evidence of a significant association between the sFlt\u20101\/PlGF ratio and OA Doppler parameters in near\u2010term pregnancies, suggesting that OA Doppler indices, particularly the PSV ratio, reflect angiogenic imbalance. Given its non\u2010invasive nature, accessibility and low cost, OA Doppler emerges as a promising surrogate tool for ruling out angiogenic imbalance. \u00a9 2026 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70270","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:44:53Z","timestamp":1782708293000},"page":"211-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ophthalmic artery\n                    <scp>Doppler<\/scp>\n                    as potential surrogate marker of angiogenic imbalance in near\u2010term pregnancy"],"prefix":"10.1002","volume":"68","author":[{"given":"M. F.","family":"Tinajero","sequence":"first","affiliation":[{"name":"BCNatal, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Faraci","sequence":"additional","affiliation":[{"name":"BCNatal, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Department of Obstetrics and Gynaecology Universit\u00e0 di Brescia, Ospedali Civili di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cuenca","sequence":"additional","affiliation":[{"name":"BCNatal, Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u  Barcelona 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