{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T09:38:05Z","timestamp":1792834685739,"version":"4.5.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize prenatal ultrasound findings in fetuses with prenatally diagnosed closed spinal dysraphism (CSD) and report their postnatal management and functional outcomes at 18 and 36\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included all fetuses with a prenatal diagnosis of CSD assessed between January 2014 and December 2024 at two tertiary centers (Fetal Medicine Department of Trousseau Hospital, Paris, France, and Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium). Lesions were reassessed and classified according to the updated Orphanet classification system for dysraphisms. Cases of open dysraphism, intermediate forms, Currarino syndrome, caudal regression syndrome and postnatally diagnosed cases were excluded. Prenatal imaging findings, pregnancy outcomes, postnatal diagnostic concordance, neurosurgical management and functional outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy fetuses with a prenatal diagnosis of CSD were included. Saccular forms of CSD accounted for 85.7% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200960) of cases, including 33 (47.1%) cases of limited dorsal myeloschisis, 18 (25.7%) cases of posterior meningocele and nine (12.9%) cases of conus spinal cord lipoma. Most (85.7%) lesions were located at the lumbar or sacral level. Associated structural cerebral anomalies were identified prenatally in 17.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912) of cases. There were 59 (84.3%) live births and 11 (15.7%) terminations of pregnancy, including eight cases with major cerebral anomalies. Among liveborn infants with available data on postnatal surgical interventions (\n                      <jats:italic>n\/N<\/jats:italic>\n                      \u2009=\u200944\/59), postnatal surgery was performed in 90.9% of cases. The prenatal diagnosis was adjusted postnatally in 4\/39 (10.3%) cases with available postnatal outcome data. At 36\u2009months, independent ambulation was achieved in 94.4% (17\/18) of children with follow\u2010up data available at this time point. In contrast, urinary dysfunction was present in 38.9% of cases at 36\u2009months, while gastrointestinal disorders were less frequent (22.2%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Using the Orphanet classification, prenatal ultrasound examination allows reliable anatomical characterization of CSD in 89.7% of cases. Motor outcomes are generally favorable, whereas urological morbidity is observed in nearly half of cases at 18\u2009months. These are important elements to consider in prenatal counseling. \u00a9 2026 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70340","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:29:51Z","timestamp":1789892991000},"page":"518-526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal findings and postnatal outcomes in cases of closed spinal dysraphism: 10\u2010year two\u2010center cohort study"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2665-8292","authenticated-orcid":false,"given":"Y.","family":"Athiel","sequence":"first","affiliation":[{"name":"Fetal Medicine Department and National Referral Center for Rare Diseases Spin@, H\u00f4pital Armand Trousseau APHP Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Van den Eede","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division Woman and Child University Hospitals Leuven Leuven Belgium"},{"name":"Academic Department Development and Regeneration Woman and Child, Biomedical Sciences, KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"de Saint Denis","sequence":"additional","affiliation":[{"name":"Pediatric Orthopedic Surgery Department, H\u00f4pital Armand\u2010Trousseau APHP Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2594-5428","authenticated-orcid":false,"given":"E.","family":"Blondiaux","sequence":"additional","affiliation":[{"name":"Pediatric Radiology Department, H\u00f4pital Armand\u2010Trousseau APHP Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Dhombres","sequence":"additional","affiliation":[{"name":"Fetal Medicine Department and National Referral Center for Rare Diseases Spin@, H\u00f4pital Armand Trousseau APHP Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5489-3121","authenticated-orcid":false,"given":"P.","family":"Maurice","sequence":"additional","affiliation":[{"name":"Fetal Medicine Department and National Referral Center for Rare Diseases Spin@, H\u00f4pital Armand Trousseau APHP Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3897-5386","authenticated-orcid":false,"given":"A.","family":"Dugas","sequence":"additional","affiliation":[{"name":"Fetal Medicine Department and National Referral Center for Rare Diseases Spin@, H\u00f4pital Armand Trousseau APHP Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Simonnet","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, H\u00f4pital Armand\u2010Trousseau APHP Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4695-9519","authenticated-orcid":false,"given":"L.","family":"Guilbaud","sequence":"additional","affiliation":[{"name":"Fetal Medicine Department and National Referral Center for Rare Diseases Spin@, H\u00f4pital Armand Trousseau APHP Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Garel","sequence":"additional","affiliation":[{"name":"Pediatric Radiology Department, H\u00f4pital Armand\u2010Trousseau APHP Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1381-4033","authenticated-orcid":false,"given":"H.","family":"van der Merwe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division Woman and Child University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1994-5365","authenticated-orcid":false,"given":"M.","family":"Aertsen","sequence":"additional","affiliation":[{"name":"Department of Radiology UZ Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Devloo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery UZ Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-4684","authenticated-orcid":false,"given":"R.","family":"Devlieger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division Woman and Child University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-945X","authenticated-orcid":false,"given":"J.","family":"Deprest","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Division Woman and Child University Hospitals Leuven Leuven Belgium"},{"name":"Academic Department Development and Regeneration Woman and Child, Biomedical Sciences, KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7890-3790","authenticated-orcid":false,"given":"J.\u2010M.","family":"Jouannic","sequence":"additional","affiliation":[{"name":"Fetal Medicine Department and National Referral Center for Rare Diseases Spin@, H\u00f4pital Armand Trousseau APHP Sorbonne Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-025-06287-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-025-03856-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.70054"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6454"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6800"},{"key":"e_1_2_7_7_1","first-page":"326","article-title":"Limited dorsal myeloschisis: from antenatal screening to postnatal evolution. About a series of cases from the Grand Est, Bourgogne and Franche\u2010Comt\u00e9","volume":"53","author":"Thomas H","year":"2025","journal-title":"Gynecol Obstet Fertil Senol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6618"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519060"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2022.102352"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41393-019-0385-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6685"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.70340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/uog.70340","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.70340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:49:47Z","timestamp":1792831787000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.70340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,20]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/uog.70340"],"URL":"https:\/\/doi.org\/10.1002\/uog.70340","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,20]]},"assertion":[{"value":"2026-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}