{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:55:16Z","timestamp":1791316516333,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the risk of pre\u2010eclampsia (PE) in triplet pregnancies, with and without embryo reduction, compared to singleton and twin pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective multicenter study of triplet pregnancies with three live, phenotypically normal fetuses at the 11\u201313\u2010week scan and a gestational age at delivery of \u2265\u200924\u2009weeks. The competing\u2010risks model was used to determine the distribution of gestational age at delivery with PE in each type of triplet pregnancy, which was compared to datasets from 1169 twin pregnancies and 61\u2009174 singleton pregnancies from previous cohorts. The relative risks of PE with delivery &lt;\u200937, &lt;\u200934 and &lt;\u200932\u2009weeks' gestation for non\u2010reduced and reduced triplet pregnancies, in comparison with twin and singleton pregnancies, were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 1020 triplet pregnancies were included, of which 456 had expectant management, 468 were reduced to twin pregnancies and 96 were reduced to singleton pregnancies. The incidence of PE with delivery &lt;\u200937\u2009weeks' gestation was 9.9% for non\u2010reduced triplet pregnancies, 9.8% for triplet pregnancies reduced to twins, 2.1% for triplet pregnancies reduced to singleton, 7.0% for twin pregnancies and 0.8% for singleton pregnancies. The incidence of\u00a0PE with delivery &lt;\u200934\u2009weeks was 7.2% for non\u2010reduced triplets, 4.1% for triplets reduced to twins, 0% for triplets reduced to singleton, 0.9% for twins and 0.4% for singletons. In comparison with singleton pregnancies, for non\u2010reduced triplets, the relative risks for PE with delivery &lt;\u200937 and &lt;\u200934\u2009weeks were 12.3 (95%\u2009CI, 9.1\u201316.3) and 20.6 (95%\u2009CI, 14.4\u201329.2), respectively. The respective values for triplet pregnancies reduced to twins were 12.2 (95%\u2009CI, 9.1\u201316.2) and 11.6 (95%\u2009CI, 7.3\u201318.2), and for triplet pregnancies reduced to singleton they were 2.6 (95%\u2009CI, 0.7\u20139.1) and 0.0 (95%\u2009CI, 0.0\u201311.0). In comparison with twin pregnancies, for non\u2010reduced triplets the relative risks for PE with delivery &lt;\u200937 and &lt;\u200934\u2009weeks were 1.4 (95%\u2009CI, 1.0\u20132.0) and 7.7 (95%\u2009CI, 4.0\u201314.9), respectively. The respective values for triplets reduced to twins were 1.4 (95%\u2009CI, 1.0\u20132.0) and 4.3 (95%\u2009CI, 2.1\u20138.9). For a given set of maternal characteristics and medical history, a non\u2010reduced triplet pregnancy was estimated to deliver with PE, on average, 14.5\u2009weeks earlier than would a singleton pregnancy. Triplet pregnancies reduced to twins were estimated to deliver with PE 12.7\u2009weeks earlier, and those reduced to singleton 6.5\u2009weeks earlier, than would comparable singleton pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Non\u2010reduced triplet pregnancies have a 21\u2010fold and 8\u2010fold higher risk of delivery with PE at &lt;\u200934\u2009weeks' gestation compared with singleton and twin pregnancies, respectively. In triplet pregnancies reduced to twins, the relative risk of PE &lt;\u200934\u2009weeks is 4\u2010fold higher than that in twin pregnancies, whereas in triplet pregnancies reduced to singleton, the risk is similar to that of singleton pregnancies. \u00a9 2026 The Author(s).\n                      <jats:italic>Ultrasound in Obstetrics &amp; Gynecology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.70341","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:06:42Z","timestamp":1789848402000},"page":"504-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of pre\u2010eclampsia in triplet pregnancies with and without embryo reduction"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9214-740X","authenticated-orcid":false,"given":"G.","family":"Yerlikaya\u2010Schatten","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Obstetrics and Feto\u2010Maternal Medicine Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wright","sequence":"additional","affiliation":[{"name":"Institute of Health Research University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-4738","authenticated-orcid":false,"given":"S.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Centre for Fetal Medicine, Pregnancy and Ultrasound, Department of Gynecology, Fertility and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8517-4082","authenticated-orcid":false,"given":"O. B.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Centre for Fetal Medicine, Pregnancy and Ultrasound, Department of Gynecology, Fertility and Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8041-2181","authenticated-orcid":false,"given":"P.","family":"Chaveeva","sequence":"additional","affiliation":[{"name":"University Hospital of Obstetrics and Gynecology \u2018Maichin dom\u2019  Sofia Bulgaria"},{"name":"Fetal Medicine Unit, Dr. Shterev Hospital  Sofia Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4921-0047","authenticated-orcid":false,"given":"A. J.","family":"Vivanti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, DMU Sant\u00e9 des Femmes et des Nouveau\u2010n\u00e9s, H\u00f4pital Antoine B\u00e9cl\u00e8re Paris Saclay University, AP\u2010HP  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9028-9597","authenticated-orcid":false,"given":"N.","family":"Persico","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS ca' Granda Ospedale Maggiore Policlinico and University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9190-5654","authenticated-orcid":false,"given":"F. S.","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hospital Universitario Cl\u00ednico San Cecilio  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria Ibs.GRANADA  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9884-5778","authenticated-orcid":false,"given":"L.","family":"Lewi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospitals Leuven  Leuven Belgium"},{"name":"Department of Development and Regeneration KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Litwinska","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynaecology Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1266-0711","authenticated-orcid":false,"given":"K. 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