{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T22:11:22Z","timestamp":1775859082480,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,4]],"date-time":"2010-01-04T00:00:00Z","timestamp":1262563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the predictive values of three ultrasonographic parameters: placental thickness (PT), fetal cardiothoracic ratio (CTR) and middle cerebral artery peak systolic velocity (MCA\u2010PSV), alone or in combination, in pregnancies affected by homozygous \u03b1<jats:sup>0<\/jats:sup>\u2010thalassemia at 12\u201320 weeks' gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnant women at risk of carrying a fetus affected by homozygous \u03b1<jats:sup>0<\/jats:sup>\u2010thalassemia were studied from 1995 to 2006 using serial ultrasonography at 12\u201315 weeks, 16\u201320 weeks and 30 weeks' gestation. We measured CTR and PT from 1995, and MCA\u2010PSV as well from 1997. An invasive prenatal test was offered if cardiomegaly with or without placentomegaly was detected but the MCA\u2010PSV results were used only retrospectively for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of a total of 777 at\u2010risk fetuses studied, 138 (17.8%) were affected by homozygous \u03b1<jats:sup>0<\/jats:sup>\u2010thalassemia. At 12\u201315 weeks' gestation, 598 ultrasound examinations were performed. CTR was better than both PT and MCA\u2010PSV in the prediction of affected pregnancies. The highest sensitivity (98.3%) was achieved by the combination of CTR and\/or MCA\u2010PSV at a false\u2010positive rate of 15.8%. At 16\u201320 weeks' gestation, 410 ultrasound examinations were performed, 121 of which were at the patient's first visit and 289 of which were at a follow\u2010up visit. Both CTR and MCA\u2010PSV predicted the affected pregnancies equally well. The sensitivity of CTR was 100.0%, but the false\u2010positive rate was 5.2%. In contrast, the false\u2010positive rate of MCA\u2010PSV alone was 1.4% and that of the combination of CTR and MCA\u2010PSV was 0%, although their sensitivities were less than 65%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The data suggest that adding MCA\u2010PSV to CTR in the prediction of homozygous \u03b1<jats:sup>0<\/jats:sup>\u2010thalassemia can increase the sensitivity at 12\u201315 weeks and decrease the false\u2010positive rate at 16\u201320 weeks' gestation. Copyright \u00a9 2010 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.7443","type":"journal-article","created":{"date-parts":[[2010,1,4]],"date-time":"2010-01-04T10:01:51Z","timestamp":1262599311000},"page":"149-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Ultrasonographic prediction of homozygous \u03b1<sup>0<\/sup>\u2010thalassemia using placental thickness, fetal cardiothoracic ratio and middle cerebral artery Doppler: alone or in combination?"],"prefix":"10.1002","volume":"35","author":[{"given":"K. Y.","family":"Leung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. B.","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. P.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. 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