{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:57:15Z","timestamp":1787684235967,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,2,8]],"date-time":"2010-02-08T00:00:00Z","timestamp":1265587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In patients with a left\u2010sided congenital diaphragmatic hernia (CDH), the left ventricle (LV) is often compressed and smaller than normal. The objective of this study was to investigate whether small left heart dimensions prenatally normalize after birth in patients with CDH, or whether prenatal indices of left heart size and flow predict postnatal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and echocardiographic data were reviewed for patients diagnosed with left\u2010sided CDH prenatally. Cardiac dimensions and flows were compared with normative data. Among liveborn patients, pre\u2010 and postnatal Z\u2010scores of left heart structures were compared, and associations between prenatal indices and outcome were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 125 patients diagnosed prenatally with CDH, 111 had a left\u2010sided defect. Of these, 85 were liveborn, including 20 with congenital heart disease. Gestational age\u2010adjusted dimensions of fetal left heart structures, including aortic valve diameter, mitral valve (MV) diameter, LV long\u2010axis, LV short\u2010axis and LV volume, were all smaller than normal (<jats:italic>P<\/jats:italic> &lt; 0.001). On average, the LV contributed 33 \u00b1 8% of combined ventricular output, lower than the normal 40\u201350%. Z\u2010scores of left heart structures increased from the prenatal echocardiogram to the postnatal study, with average changes ranging from 0.56 \u00b1 1.68 (aortic valve) to 1.39 \u00b1 1.85 (LV volume). Among liveborn patients, there was no association between prenatal left heart Z\u2010scores and postnatal survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hypoplasia of and reduced flow through the left heart are common among fetuses with CDH. After birth and CDH repair, left heart dimensions generally normalize, with adequate size to support a biventricular circulation, even when there is very low flow through the left heart in mid\u2010 and late\u2010gestation. Copyright \u00a9 2010 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.7497","type":"journal-article","created":{"date-parts":[[2010,2,8]],"date-time":"2010-02-08T14:28:29Z","timestamp":1265639309000},"page":"310-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Significance and outcome of left heart hypoplasia in fetal congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"35","author":[{"given":"M.","family":"Vogel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. B.","family":"McElhinney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Morash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W.","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Tworetzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(99)90360-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0041-87812001000600003"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90183-4"},{"key":"e_1_2_6_5_2","first-page":"350","article-title":"The fetal heart in diaphragmatic hernia","volume":"76","author":"Allan LD","year":"1996","journal-title":"Heart"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90314-3"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(84)80105-0"},{"key":"e_1_2_6_8_2","first-page":"34","article-title":"Cardiopulmonary consequences of congenital diaphragmatic hernia","volume":"16","author":"O'Toole SJ","year":"1996","journal-title":"J Perinatol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83293-7"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70178-7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1993.03020093.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050457"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.5.1068"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00429-4"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.71.1.70"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)37741-4"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01144.2004"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90238-4"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.6.1208"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2832"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.12.1662"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2813"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.09.018"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.7497","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.7497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T08:37:29Z","timestamp":1696754249000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.7497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,8]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1002\/uog.7497"],"URL":"https:\/\/doi.org\/10.1002\/uog.7497","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,8]]},"assertion":[{"value":"2009-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}