{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:52:43Z","timestamp":1790805163144,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T00:00:00Z","timestamp":1261440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aims of this study were to establish normal ranges of values for interlens distance (ILD) during gestation, and to assess the correlation between ILD and growth of the orbits and other fetal biometric parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study of morphologically normal, singleton fetuses was carried out in low\u2010risk pregnant women. We measured the distance between the centers of the fetal lenses from 12 to 37 completed weeks of gestation. An oblique anterior coronal section was used to measure the ILD. The biorbital diameter (BOD) was measured in the same plane. We analyzed the correlation between the ILD and gestational age (GA), BOD, biparietal diameter (BPD), head circumference (HC), femur length (FL) and abdominal circumference (AC). Fetal gender was assessed to evaluate possible significant differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and fifty normal fetuses were recruited for the study. In 427 fetuses appropriate ILD measurements were obtained, and complete evaluation of all parameters was accomplished in 377 of these. ILD demonstrated a high positive correlation with GA (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.969), BPD (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.959), HC (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.962), AC (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.949) and FL (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.956) as pregnancy advanced. The mean BOD : ILD ratio was 1.50 \u00b1 0.08, remaining constant throughout pregnancy (linear regression <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.006). No statistically significant differences were found between genders for mean ILD and GA of the study population (<jats:italic>P<\/jats:italic> = 0.604 and 0.595, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study confirm previous hypotheses regarding the close relationship between eyeball growth and growth of the surrounding bony structures. Measurement of fetal ILD, which can be used interchangeably with BOD measurement in either the axial or coronal plane, can be taken to reflect the expected development of the fetal orbits whilst simultaneously providing valuable information on eyeball development. It is likely that ILD could be used as a complementary tool in the elaboration of various severe abnormalities, mainly related to craniofacial and nervous system malformations. Copyright \u00a9 2010 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.7531","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T13:24:08Z","timestamp":1261488248000},"page":"186-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Fetal interlens distance: normal values during pregnancy"],"prefix":"10.1002","volume":"36","author":[{"given":"Z.","family":"Kivilevitch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Salomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Benoit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Achiron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,28]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"443","article-title":"First\u2010 and second\u2010trimester diagnosis of fetal ocular defects and associated anomalies: Report of eight cases","volume":"77","author":"Bronshtein M","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970150208"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200011)20:11<894::AID-PD949>3.0.CO;2-J"},{"issue":"2","key":"e_1_2_5_5_2","article-title":"Fetal ocular and orbital development in humans","volume":"12","author":"Tomasik E","year":"2004","journal-title":"Durham Anthropol J"},{"key":"e_1_2_5_6_2","first-page":"225","volume-title":"Fundamentals of Craniofacial Growth","author":"Hoyte DAN","year":"1997"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1475-1313.2002.00023.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13006.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11010030.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3911"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(82)90581-6"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.2.6803295"},{"key":"e_1_2_5_13_2","first-page":"2232","article-title":"A biometric study of the eye, orbit, and face in 205 normal human fetuses","volume":"39","author":"Denis D","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2003.22.11.1201"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199009000-00001"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(70)90503-9"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199331010-00005"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199909030-00015"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.12030175.x"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.7531","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.7531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T09:21:55Z","timestamp":1696670515000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.7531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,28]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1002\/uog.7531"],"URL":"https:\/\/doi.org\/10.1002\/uog.7531","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,28]]},"assertion":[{"value":"2009-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}