{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:04:19Z","timestamp":1783069459329,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T00:00:00Z","timestamp":1263254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the neurodevelopmental outcome of children with prenatally diagnosed isolated microcephaly defined as head circumference more than 2 SD below the gestational mean.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children aged 2\u20136 years who had been diagnosed <jats:italic>in utero<\/jats:italic> as having head circumference measurements more than 2 SD below the gestational mean were compared with normocephalic children, utilizing a standard neuropsychological battery. Comparisons were also made within the study group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HCs were between \u22122 and \u22124.8 SD, only one fetus having a HC below \u22123 SD. Children with a prenatal head circumference between 2 SD and 3 SD below the gestational mean did not differ significantly from the control group regarding cognitive, language and motor functioning. However, they exhibited more behavioral\u2010emotional problems. There were no significant differences between children who had suffered from intrauterine growth restriction and those who had not, or between those with familial and those with non\u2010familial microcephaly. Nevertheless, linear regression analysis showed that head circumference <jats:italic>in utero<\/jats:italic> helps predict cognitive functioning later in life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prenatally diagnosed head circumference between 2 SD and 3 SD below the gestational mean is not a risk factor for later abnormal neuropsychological development. Copyright \u00a9 2010 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.7556","type":"journal-article","created":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T20:09:57Z","timestamp":1263326997000},"page":"154-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Developmental outcome of isolated fetal microcephaly"],"prefix":"10.1002","volume":"36","author":[{"given":"S.","family":"Stoler\u2010Poria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Lev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Schweiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Lerman\u2010Sagie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Malinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90027-9"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000183747.05269.2d"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.11050317.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.01.003"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yapd.2005.04.003"},{"key":"e_1_2_5_7_2","first-page":"175","article-title":"Microcephaly: General considerations and aids to nosology","volume":"10","author":"Opitz JM","year":"1990","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.452"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2007.07.003"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.06.006"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00743.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1995.14.4.303"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1985.tb03798.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1542\/peds.59.2.262","article-title":"Microcephly in normal school population","volume":"59","author":"Sells CJ","year":"1977","journal-title":"Pediatrics"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2005.11.022"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-1-110"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08212.x"},{"key":"e_1_2_5_18_2","volume-title":"Bayley Scale of Infant and Toddler Development","author":"Bayley N","year":"2006"},{"key":"e_1_2_5_19_2","volume-title":"Kaufman Assessment Battery for Children","author":"Kaufman AS","year":"1983"},{"key":"e_1_2_5_20_2","volume-title":"Peabody Picture Vocabulary Test","author":"Dunn LM","year":"2007"},{"key":"e_1_2_5_21_2","volume-title":"WRAVMA. 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