{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:03:22Z","timestamp":1773745402528,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T00:00:00Z","timestamp":1265155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify independent predictors of adverse neonatal outcome in cases of fetal growth restriction (FGR) at \u2265 34 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From a cohort of 481 FGR cases delivered at \u2265 34 weeks, demographic and obstetric variables, fetal biometry and Doppler indices of the uterine, umbilical and fetal middle cerebral arteries available within 2 weeks of delivery, were related to adverse neonatal outcome, defined as admission to the neonatal intensive care unit for indications other than low birth weight alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Logistic regression analysis showed that gestational age (GA) at delivery (odds ratio (OR) = 0.59; 95% CI, 0.50\u20130.70), abdominal circumference (AC) centile (OR = 0.69; 95% CI, 0.59\u20130.81) and umbilical artery (UA) pulsatility index (PI) centile (OR = 1.02; 95% CI, 1.01\u20131.04) significantly correlated with adverse neonatal outcome. From this model we calculated a score of adverse neonatal outcome expressed by the formula: (UA\u2010PI centile\/3) \u2212 (10 \u00d7 AC centile) + (10 \u00d7 (40 \u2212 GA at delivery in weeks)). Receiver\u2013operating characteristics curve analysis demonstrated that a score of \u2265 25 optimally predicted adverse neonatal outcome (sensitivity of 75%, false\u2010positive rate of 18%). Beyond 37.5 weeks, gestational age no longer had an independent impact on outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In late preterm or term FGR, GA at delivery is the most important predictor of adverse neonatal outcome. At &gt; 37.5 weeks, delivery may be the best option to minimize adverse outcome in all FGR cases. At 34\u201337 weeks, a score based on GA at delivery, UA\u2010PI centile and AC centile optimally predicts adverse neonatal outcome. Copyright \u00a9 2010 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.7583","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T11:55:10Z","timestamp":1265198110000},"page":"166-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Can adverse neonatal outcome be predicted in late preterm or term fetal growth restriction?"],"prefix":"10.1002","volume":"36","author":[{"given":"P.","family":"Vergani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Roncaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ghidini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Crippa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Cameroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Orsenigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pezzullo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200606000-00008"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904223401603"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.082297"},{"key":"e_1_2_5_5_2","volume-title":"Intrauterine growth restriction.","author":"American College of Obstetricians and Gynecologists","year":"2000"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90466-2"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.11.3.199.203"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00079.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.213.3.r99dc08681"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70283-8"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.127137"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00836-6"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13077.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198912000-00007"},{"key":"e_1_2_5_15_2","first-page":"277","article-title":"Systolic and diastolic notch in uterine artery blood flow velocity waveforms in hypertensive pregnant patients: relationship to outcome","volume":"80","author":"Thaler I","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1990.9.5.249"},{"key":"e_1_2_5_17_2","first-page":"649","article-title":"Qualitative assessment of uteroplacental blood flow: early screening test for high\u2010risk pregnancies","volume":"68","author":"Campbell S","year":"1986","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_18_2","first-page":"203","article-title":"Standard del peso alla nascita in Italia","volume":"112","author":"Parazzini F","year":"1991","journal-title":"Ann Ostet Ginecol Med Perinat"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2008.02.008"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02014.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050600852510"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2657"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0395"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb11916.x"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.7583","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.7583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T09:21:01Z","timestamp":1696670461000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.7583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,28]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1002\/uog.7583"],"URL":"https:\/\/doi.org\/10.1002\/uog.7583","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,28]]},"assertion":[{"value":"2009-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}