{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:53:08Z","timestamp":1781578388187,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,7,12]],"date-time":"2010-07-12T00:00:00Z","timestamp":1278892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish a normal range of nasal\u2010bone length at 16\u201324 weeks' gestation by the use of three\u2010dimensional (3D) ultrasound and to investigate the effect of deviations from the exact mid\u2010sagittal plane on the measurement of nasal\u2010bone length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We acquired 3D volumes of the fetal profile from 135 normal fetuses at 16\u201324 weeks' gestation. The multiplanar mode was used to obtain the exact mid\u2010sagittal plane and to produce parasagittal and oblique views of the fetal face. Nasal\u2010bone length was measured in each plane and the sonographic landmarks of each profile view were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nasal\u2010bone length increased with gestational age from a mean of 4.1 mm at 16 weeks to 7.1 mm at 24 weeks. There was a tendency to underestimate nasal\u2010bone length when the measurements were taken in parasagittal planes and to overestimate the measurements when they were taken in oblique views, compared to the exact mid\u2010sagittal plane. The mean difference in nasal\u2010bone length from the one in the mid\u2010sagittal plane was 0.42 and 0.63 mm for parasagittal measurements at 1 and 2 mm, respectively, from the midline, \u22120.08 and \u22120.51 mm for oblique measurements at 10\u00b0 and 20\u00b0 rotation along the <jats:italic>z<\/jats:italic>\u2010axis and \u22120.69 mm for rotation of 20\u00b0 along the <jats:italic>z<\/jats:italic>\u2010axis and 10\u00b0 along the <jats:italic>y<\/jats:italic>\u2010axis. The vomeral bone was the only sonographic landmark defining the exact mid\u2010sagittal plane of the face that was not visible in the parasagittal and oblique planes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Parasagittal and oblique scanning planes may produce different degrees of under\u2010 or over\u2010estimation of nasal\u2010bone length compared to measurements systematically taken in the exact mid\u2010sagittal plane. Inclusion of the vomeral bone in the definition of the exact mid\u2010sagittal plane of the face could improve the reproducibility of measurements of nasal\u2010bone length. Copyright \u00a9 2010 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.7745","type":"journal-article","created":{"date-parts":[[2010,7,13]],"date-time":"2010-07-13T18:46:51Z","timestamp":1279046811000},"page":"285-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Nasal\u2010bone length in euploid fetuses at 16\u201324 weeks' gestation by three\u2010dimensional ultrasound"],"prefix":"10.1002","volume":"36","author":[{"given":"N.","family":"Persico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Borenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Azumendi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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