{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T05:14:14Z","timestamp":1696828454935},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,24]],"date-time":"2011-01-24T00:00:00Z","timestamp":1295827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether, at the time of ultrasound\u2010indicated cerclage, the endocervical concentration of hyaluronan (HA), 27\u2010kDa heat shock protein (HSP\u201027) and\/or interleukin\u20108 (IL\u20108) would predict pregnancy outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Endocervical samples, obtained from 40 women undergoing ultrasound\u2010indicated cerclage at 15 + 3 to 25 + 0 weeks' gestation, were assayed by enzyme\u2010linked immunosorbent assay for HA, HSP\u201027 and IL\u20108. All subjects had a cervical length of &lt; 1.5 cm or dramatic cervical length change on serial endovaginal ultrasound, no uterine contractions or tenderness, no fever and intact membranes and underwent a modified Shirodkar cerclage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median HA level was 10.0 ng\/mL in the 12 women who delivered at &lt; 37 weeks' gestation as opposed to 39.7 ng\/mL in the 28 women delivering at 37\u201341 weeks (<jats:italic>P<\/jats:italic> = 0.017). Median HSP\u201027 and IL\u20108 concentrations were not significantly different in these groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A higher endocervical HA level at the time of ultrasound\u2010indicated cerclage is associated with a longer interval before birth. Copyright \u00a9 2011 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.7756","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T12:36:59Z","timestamp":1279888619000},"page":"214-218","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endocervical hyaluronan and ultrasound\u2010indicated cerclage"],"prefix":"10.1002","volume":"37","author":[{"given":"G. S.","family":"Eglinton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Herway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. W.","family":"Skupski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Bongiovanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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