{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:36:23Z","timestamp":1775738183379,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,3,23]],"date-time":"2011-03-23T00:00:00Z","timestamp":1300838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp;amp; Gyne"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Low\u2010resistance hepatic artery (HA) flow has been reported in severely growth\u2010restricted fetuses. The same finding has been incidentally observed in first\u2010trimester fetuses with enlarged nuchal translucency (NT). The aim of this study was to investigate HA flow in first\u2010trimester fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Crown\u2013rump length (CRL), NT, ductus venosus (DV) pulsatility index for veins (PIV) and HA pulsatility index (PI) were measured prospectively in fetuses at increased risk on first\u2010trimester assessment for aneuploidy and in a control group of low\u2010risk fetuses. Outcome of pregnancy was known in all cases. Independent sample <jats:italic>t<\/jats:italic>\u2010test was used for intergroup comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NT, DV\u2010PIV and HA\u2010PI were measured prospectively in 59 fetuses. Thirty\u2010four had an enlarged NT and underwent karyotyping, which was abnormal in 16 cases (trisomy 21, <jats:italic>n<\/jats:italic> = 12; trisomy 18, <jats:italic>n<\/jats:italic> = 3; 47,XXY, <jats:italic>n<\/jats:italic> = 1). Two pregnancies were terminated in view of fetal anomalies. In three other infants an abnormality was confirmed after birth (Noonan syndrome, unspecified genetic syndrome and cardiac defect). The remaining 13 fetuses with enlarged NT and the 25 with normal NT had an uneventful pregnancy outcome. HA\u2010PI was significantly and inversely correlated with NT and DV\u2010PIV. Mean HA\u2010PI was significantly lower in fetuses with adverse outcome (chromosomal anomalies 1.60; chromosomally normal fetuses with adverse outcome 1.66) than in controls (2.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low\u2010resistance HA flow can be observed in first\u2010trimester fetuses and, based on its association with adverse outcome, it can be regarded as an ominous sign. Copyright \u00a9 2011 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.7766","type":"journal-article","created":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T16:07:51Z","timestamp":1286208471000},"page":"438-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Low\u2010resistance hepatic artery flow in first\u2010trimester fetuses: an ominous sign"],"prefix":"10.1002","volume":"37","author":[{"given":"C. M.","family":"Bilardo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Timmerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. G.","family":"Robles De Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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