{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:20:04Z","timestamp":1778070004226,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,7,28]],"date-time":"2011-07-28T00:00:00Z","timestamp":1311811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The primary aim of this study was to assess pregnant women's knowledge of first\u2010trimester combined Down syndrome screening in a setting of required informed consent. As the secondary aim, we wanted to identify relevant differences in knowledge level among subgroups of pregnant women, including those informed in different ways about prenatal examinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data stem from a population\u2010based cross\u2010sectional questionnaire study including 15 multiple\u2010choice questions assessing knowledge of different aspects of screening. Included were 6427 first\u2010trimester pregnant women from three Danish obstetric departments offering prenatal screening free of charge. Both participants and non\u2010participants in the screening program were included. The results are based on 4095 responders (64%). Differences between subgroups were examined using chi\u2010squared tests and logistic regression analysis. Estimates are stated with 95% CI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of the participants (87.6 (86.6\u201388.6)% to 92.6 (91.7\u201393.3)%) correctly identified the test concept and the main condition being screened for. Fewer participants (16.4 (15.3\u201317.6)% to 43.3 (41.8\u201344.8)%) correctly recognized test accuracy and the potential risk of adverse findings other than Down syndrome. Knowledge level was positively associated with length of education (adjusted ORs 1.0 (0.8\u20131.4) to 3.9 (2.4\u20136.4)) and participation in the screening program (adjusted OR 0.9 (0.6\u20131.3) to 5.9 (3.9\u20138.8)). Participation in an individual information session was weakly associated with more knowledge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of the pregnant women correctly identified the test concept and the main condition being screened for. The pregnant women were found less knowledgeable on test accuracy and drawbacks. Copyright \u00a9 2011 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.8839","type":"journal-article","created":{"date-parts":[[2010,9,27]],"date-time":"2010-09-27T10:05:19Z","timestamp":1285581919000},"page":"145-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["First\u2010trimester Down syndrome screening: pregnant women's knowledge"],"prefix":"10.1002","volume":"38","author":[{"given":"K.","family":"Dahl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hvidman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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