{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:01:37Z","timestamp":1781560897528,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,1,25]],"date-time":"2011-01-25T00:00:00Z","timestamp":1295913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the prevalence of previously undiagnosed cardiac structural abnormalities in pregnant women with normal\u2010 and high\u2010resistance midtrimester uterine artery Doppler indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Maternal <jats:italic>transthoracic<\/jats:italic> echocardiography was undertaken in <jats:italic>asymptomatic<\/jats:italic> pregnant women after uterine artery Doppler screening for pre\u2010eclampsia at 21\u201323 weeks' gestation. Women with a mean uterine artery pulsatility index above the 90<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile (1.25) for the local population (multiethnic, socially diverse and migrant) were considered to have high\u2010resistance uteroplacental blood flow indices. The prevalence of <jats:italic>newly diagnosed<\/jats:italic> cardiac structural defects in these women was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 491 women underwent echocardiography, of whom 205 had high\u2010resistance uterine artery blood flow indices. There were nine previously undiagnosed, functionally significant cardiac defects in the high\u2010resistance uterine artery blood flow group and only one, functionally insignificant cardiac defect in the normal\u2010resistance group (<jats:italic>P<\/jats:italic> = 0.005; relative risk = 12.6, 95% confidence interval, 1.60\u201398.34). Multiple regression analysis demonstrated that both uterine artery Doppler indices (<jats:italic>P<\/jats:italic> = 0.024) and ethnicity (<jats:italic>P<\/jats:italic> = 0.048) contributed independently towards a higher prevalence of cardiac defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of previously undiagnosed maternal cardiac structural abnormalities is significantly increased in women with high midtrimester uterine artery Doppler resistance indices. This observation has important consequences for the current and long\u2010term medical care provided to these patients. Detailed maternal cardiac assessment with echocardiography may be required in migrant women with high uterine artery Doppler indices. Copyright \u00a9 2011 ISUOG. 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