{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:09:27Z","timestamp":1773295767375,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T00:00:00Z","timestamp":1313539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate longitudinally a cohort of twin pregnancies and to assess whether the occurrence of adverse pregnancy outcome may be related to specific maternal cardiac findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women with twin pregnancies were enrolled prospectively and underwent serial maternal echocardiography at 20\u201323 weeks, 26\u201329 weeks and 30\u201333 weeks of gestation. Patients were excluded if delivery took place prior to 34 weeks. Cardiac findings were compared between patients with uneventful pregnancy outcome and those who developed one of the following complications: pre\u2010eclampsia or gestational hypertension; small\u2010for\u2010gestational age (SGA) neonates (birth weight of one or both twins &lt; 5<jats:sup><jats:italic>th<\/jats:italic><\/jats:sup> centile for gestational age).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A group of 28 twin gestations was obtained for analysis, including eight complicated cases. At each visit, mean \u00b1 SD cardiac output (CO) was significantly higher in uncomplicated than complicated twin pregnancies (6.55 \u00b1 0.82 vs 4.99 \u00b1 0.67 L\/min, <jats:italic>P<\/jats:italic> &lt; 0.001 at 20\u201323 weeks; 7.31 \u00b1 0.74 vs 5.66 \u00b1 1.17 L\/min, <jats:italic>P<\/jats:italic> &lt; 0.001 at 26\u201329 weeks; 7.50 \u00b1 0.89 vs 5.32 \u00b1 0.74 L\/min, <jats:italic>P<\/jats:italic> &lt; 0.001 at 30\u201333 weeks), as was stroke volume (83.4 \u00b1 12.2 vs 64.5 \u00b1 9.2 mL, <jats:italic>P<\/jats:italic> = 0.001 at 20\u201323 weeks; 84.4 \u00b1 15.6 vs 64.5 \u00b1 12.0 mL, <jats:italic>P<\/jats:italic> = 0.003 at 26\u201329 weeks; 85.0 \u00b1 19.2 vs 65.6 \u00b1 10.7 mL, <jats:italic>P<\/jats:italic> = 0.013 at 30\u201333 weeks), whereas total vascular resistance (TVR) was lower (1005 \u00b1 137 vs 1406 \u00b1 159 dynes \u00d7 s\/cm<jats:sup>5<\/jats:sup>, <jats:italic>P<\/jats:italic> &lt; 0.001 at 20\u201323 weeks; 924 \u00b1 100 vs 1249 \u00b1 231 dynes \u00d7 s\/cm<jats:sup>5<\/jats:sup>, <jats:italic>P<\/jats:italic> &lt; 0.001 at 26\u201329 weeks; 929 \u00b1 96 vs 1400 \u00b1 244 dynes \u00d7 s\/cm<jats:sup>5<\/jats:sup>, <jats:italic>P<\/jats:italic> &lt; 0.001 at 30\u201333 weeks). Moreover, CO, blood pressure (BP), heart rate (HR) and TVR remained stable throughout the assessed pregnancy interval in women developing a complication, whereas significant changes (rise in CO, HR and BP; fall in TVR) were noted in the uncomplicated group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maternal cardiac function in twin pregnancies complicated by pre\u2010eclampsia or SGA neonates apparently does not undergo the profound longitudinal changes that occur in uneventful twin pregnancies. Copyright \u00a9 2011 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.8915","type":"journal-article","created":{"date-parts":[[2011,1,10]],"date-time":"2011-01-10T17:29:29Z","timestamp":1294680569000},"page":"581-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Maternal cardiac function in complicated twin pregnancy: a longitudinal study"],"prefix":"10.1002","volume":"38","author":[{"given":"T.","family":"Ghi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kuleva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Maroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pilu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pelusi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90405-8"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70297-7"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199912000-00014"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00135.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016349509021176"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.5.1209"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00847.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3901"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5311"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5231"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1095"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000298622.22494.0c"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90682-0"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200310000-00024"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8936"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000047157"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/147670410001728223"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-25313"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00865.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01013.x"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.8915","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.8915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T18:20:28Z","timestamp":1696789228000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.8915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,17]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1002\/uog.8915"],"URL":"https:\/\/doi.org\/10.1002\/uog.8915","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,17]]},"assertion":[{"value":"2010-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}