{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:35:46Z","timestamp":1776094546417,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T00:00:00Z","timestamp":1301443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the prevalence of congenital uterine anomalies in subfertile women and to evaluate their influence on early pregnancy following assisted reproduction treatment (ART).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively recruited 1402 subjects undergoing ART over a period of 5 years from 2005 to 2009. Three\u2010dimensional transvaginal sonography was performed in the early follicular phase of the menstrual cycle (days 2\u20135) and repeated in the late follicular phase (days 10\u201314) if the shape of the uterine cavity could not be assessed at the first scan. All subjects who conceived following ART were followed up to 12 weeks' gestation. Chi\u2010square test was used to compare the pregnancy rates and miscarriage rates between women shown to have uterine anomalies and those with a normal uterus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One thousand three hundred and eighty\u2010five subjects were included for final analysis after excluding 17 subjects in whom a definitive diagnosis could not be made. While 1201 (86.7%) subjects had a normal uterine cavity, uterine anomalies were demonstrated in 184 (13.3%) subjects. Arcuate uteri represented the commonest anomaly (<jats:italic>n<\/jats:italic> = 164 (11.8%)) followed by septate (<jats:italic>n<\/jats:italic> = 7 (0.5%)), unicornuate (<jats:italic>n<\/jats:italic> = 6 (0.4%)), subseptate (<jats:italic>n<\/jats:italic> = 5 (0.4%)), bicornuate (<jats:italic>n<\/jats:italic> = 1 (0.1%)) and T\u2010shaped uteri (<jats:italic>n<\/jats:italic> = 1 (0.1%)). A total of 440 subjects who underwent ART were followed up. The pregnancy rates in women with arcuate uteri (36\/66 (54.5%)) and major uterine anomalies (7\/10 (70.0%)) were statistically similar (<jats:italic>P<\/jats:italic> = 0.09 and <jats:italic>P<\/jats:italic> = 0.11, respectively) to that of the matched controls with normal uteri (158\/364 (43.4%)). While first\u2010trimester miscarriage rates were similar (<jats:italic>P<\/jats:italic> = 0.81) between the control group (20\/158 (12.7%)) and women with arcuate uteri (5\/36 (13.9%)), women with major uterine anomalies experienced a higher miscarriage rate (3\/7 (42.9%); <jats:italic>P<\/jats:italic> = 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women who are referred for ART have a high prevalence of congenital uterine anomalies, the most common anomaly being an arcuate uterus. These anomalies are not associated with a reduction in pregnancy rates following ART. However, while the arcuate uterus was not associated with an increase in first\u2010trimester miscarriage, major uterine anomalies seemed to increase the risk of first\u2010trimester miscarriage. Copyright \u00a9 2011 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.8968","type":"journal-article","created":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T14:43:24Z","timestamp":1298040204000},"page":"727-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Prevalence of uterine anomalies and their impact on early pregnancy in women conceiving after assisted reproduction treatment"],"prefix":"10.1002","volume":"37","author":[{"given":"K.","family":"Jayaprakasan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. 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J.","family":"Raine\u2010Fenning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-931798"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn018"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2003.09.001"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05040233.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.127"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011950202480"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01129532"},{"key":"e_1_2_5_9_2","first-page":"103","article-title":"1000 office\u2010based hysteroscopies prior to in vitro fertilization: feasibility and findings","volume":"8","author":"Hinckley MD","year":"2004","journal-title":"JSLS"},{"key":"e_1_2_5_10_2","first-page":"501","article-title":"Routine office hysteroscopy in the investigation of infertile couples before assisted reproduction","volume":"50","author":"de S\u00e1 Rosa e de Silva AC","year":"2005","journal-title":"J Reprod Med"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.923"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh056"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg030"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01599-X"},{"key":"e_1_2_5_15_2","unstructured":"E Vayena PJ Rowe PD Griffin 2002"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)45023-5"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0096(199711\/12)25:9<487::AID-JCU4>3.0.CO;2-J"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.05.044"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.09.069"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.8968","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.8968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T10:04:16Z","timestamp":1696759456000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.8968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,30]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1002\/uog.8968"],"URL":"https:\/\/doi.org\/10.1002\/uog.8968","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,30]]},"assertion":[{"value":"2011-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}