{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:56:56Z","timestamp":1792889816665,"version":"4.5.0"},"reference-count":102,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T00:00:00Z","timestamp":1308096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Women with a sonographic short cervix in the mid\u2010trimester are at increased risk for preterm delivery. This study was undertaken to determine the efficacy and safety of using micronized vaginal progesterone gel to reduce the risk of preterm birth and associated neonatal complications in women with a sonographic short cervix.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a multicenter, randomized, double\u2010blind, placebo\u2010controlled trial that enrolled asymptomatic women with a singleton pregnancy and a sonographic short cervix (10\u201320 mm) at 19 + 0 to 23 + 6 weeks of gestation. Women were allocated randomly to receive vaginal progesterone gel or placebo daily starting from 20 to 23 + 6 weeks until 36 + 6 weeks, rupture of membranes or delivery, whichever occurred first. Randomization sequence was stratified by center and history of a previous preterm birth. The primary endpoint was preterm birth before 33 weeks of gestation. Analysis was by intention to treat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 465 women randomized, seven were lost to follow\u2010up and 458 (vaginal progesterone gel,\n                      <jats:italic>n<\/jats:italic>\n                      = 235; placebo,\n                      <jats:italic>n<\/jats:italic>\n                      = 223) were included in the analysis. Women allocated to receive vaginal progesterone had a lower rate of preterm birth before 33 weeks than did those allocated to placebo (8.9% (\n                      <jats:italic>n<\/jats:italic>\n                      = 21) vs 16.1% (\n                      <jats:italic>n<\/jats:italic>\n                      = 36); relative risk (RR), 0.55; 95% CI, 0.33\u20130.92;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02). The effect remained significant after adjustment for covariables (adjusted RR, 0.52; 95% CI, 0.31\u20130.91;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02). Vaginal progesterone was also associated with a significant reduction in the rate of preterm birth before 28 weeks (5.1% vs 10.3%; RR, 0.50; 95% CI, 0.25\u20130.97;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.04) and 35 weeks (14.5% vs 23.3%; RR, 0.62; 95% CI, 0.42\u20130.92;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02), respiratory distress syndrome (3.0% vs 7.6%; RR, 0.39; 95% CI, 0.17\u20130.92;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.03), any neonatal morbidity or mortality event (7.7% vs 13.5%; RR, 0.57; 95% CI, 0.33\u20130.99;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.04) and birth weight &lt; 1500 g (6.4% (15\/234) vs 13.6% (30\/220); RR, 0.47; 95% CI, 0.26\u20130.85;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01). There were no differences in the incidence of treatment\u2010related adverse events between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The administration of vaginal progesterone gel to women with a sonographic short cervix in the mid\u2010trimester is associated with a 45% reduction in the rate of preterm birth before 33 weeks of gestation and with improved neonatal outcome. Copyright \u00a9 2011 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/uog.9017","type":"journal-article","created":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T12:18:50Z","timestamp":1302092330000},"page":"18-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":735,"title":["Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"38","author":[{"given":"S. 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