{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:16:25Z","timestamp":1789676185412,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T00:00:00Z","timestamp":1316476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Ultrasound in Obstet &amp; Gyne"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess trends in levels of biochemical markers, uterine artery (UtA) pulsatility index (PI) and maternal blood pressure changes over time and study their relationships in uncomplicated first\u2010trimester pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population comprised 86 women with singleton pregnancies. In each woman, a blood sample was collected at 6\u20137, 8\u20139, 10\u201311 and 12\u201313 weeks' gestation. At the same visit blood pressure was measured and ultrasound examination was performed to measure the crown\u2013rump length and Doppler flow velocity waveform patterns of both UtAs. Serum concentrations of pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A), free \u03b2\u2010human chorionic gonadotropin (\u03b2\u2010hCG), A disintegrin and metalloprotease domain\u2010containing protein\u201012 (ADAM\u201012), placental protein\u201013 (PP\u201013) and placental growth factor (PlGF) levels were measured in thawed specimens using an automated time\u2010resolved fluorescence assay. Summary curves were created to describe normal ranges and trends over time. The data were analyzed with a linear mixed model with the log\u2010transformed marker values as dependent variables. This allowed for flexible modeling of patterns over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010eight pregnancies had an uneventful outcome, with the birth of an appropriate\u2010for\u2010gestational\u2010age (AGA) infant. In these pregnancies serum PAPP\u2010A, ADAM\u201012, PP\u201013 and PlGF levels increased with gestational age. The UtA\u2010PI decreased and the mean arterial blood pressure remained constant. There were no significant correlations between maternal age, birth\u2010weight percentile, gender and blood pressure and any of the biochemical markers. The serum markers were highly correlated with each other except for \u03b2\u2010hCG. A negative correlation was found between most biomarkers and UtA\u2010PI, especially from 10 weeks onwards. Serum concentrations of ADAM\u201012 and PP\u201013 were lower in a small\u2010for\u2010gestational\u2010age (SGA) subgroup born at term (<jats:italic>n<\/jats:italic> = 6), the former statistically significantly (<jats:italic>P<\/jats:italic> = 0.031), the latter non\u2010significantly (<jats:italic>P<\/jats:italic> = 0.054), whereas UtA\u2010PI was significantly higher (<jats:italic>P<\/jats:italic> = 0.02). Biomarker concentrations in 12 women delivering a large\u2010for\u2010gestational age infant did not differ from those delivering AGA neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a relationship between biochemical markers of early placentation and downstream resistance to flow in the UtAs in low\u2010risk uncomplicated pregnancies, indicating differences in placentation. In a small series of SGA infants born at term we could demonstrate differences as compared to normal pregnancies, with potential value for screening. Copyright \u00a9 2011 ISUOG. Published by John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/uog.9029","type":"journal-article","created":{"date-parts":[[2011,4,26]],"date-time":"2011-04-26T10:59:36Z","timestamp":1303815576000},"page":"383-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Longitudinal trends in fetoplacental biochemical markers, uterine artery pulsatility index and maternal blood pressure during the first trimester of pregnancy"],"prefix":"10.1002","volume":"38","author":[{"given":"E. J.","family":"Wortelboer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P. H.","family":"Koster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. C.","family":"Eijkemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Bilardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C. J. I.","family":"Schielen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. H. A.","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8430"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.02.025"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1665"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903165198"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02690.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7439"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1989.tb03378.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.11.014"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6452"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126097-200304000-00005"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2009.09.008"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem375"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077914"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2814"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90574-1"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.2.149"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(97)90007-2"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod56.2.489"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2405"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2440"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2384"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0436"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.1.157"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1665"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/417916a"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2003.12.009"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04004.x"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.02.025"}],"container-title":["Ultrasound in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fuog.9029","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/uog.9029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T09:18:30Z","timestamp":1696670310000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/uog.9029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,20]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1002\/uog.9029"],"URL":"https:\/\/doi.org\/10.1002\/uog.9029","archive":["Portico"],"relation":{},"ISSN":["0960-7692","1469-0705"],"issn-type":[{"value":"0960-7692","type":"print"},{"value":"1469-0705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,20]]},"assertion":[{"value":"2011-03-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}